AIM: To investigate the immunopathological changes in duodenal tissues induced by strongyloidiasis and to relate these to degrees of clinical severity. METHODS: Tissues taken from 21 patients showing mild, moderate or severe symptoms of strongyloidiasis, and from non-infected controls, were sectioned and stained immunocytochemically for IgA, secretory component (SC) and HLA-DR. Immunopathology was assessed by changes in numbers, intensity and distribution of stained cells. RESULTS: Parasitised individuals showed villous atrophy and crypt hyperplasia. There was notable infiltration of the lamina propria by IgA positive plasma cells and of the epithelium by intraepithelial lymphocytes. Infection was also associated with increased expression of SC and decreased expression of HLA-DR in epithelial cells. Changes in all parameters correlated with degree of clinical severity. CONCLUSIONS: Profound mucosal changes are induced by strongyloidiasis. Some are analogous to those seen in coeliac disease, but others seem quite unusual. It is likely that these changes are functionally related to the immunopathophysiological consequences of infection seen in patients with severe disease.
AIM: To investigate the immunopathological changes in duodenal tissues induced by strongyloidiasis and to relate these to degrees of clinical severity. METHODS: Tissues taken from 21 patients showing mild, moderate or severe symptoms of strongyloidiasis, and from non-infected controls, were sectioned and stained immunocytochemically for IgA, secretory component (SC) and HLA-DR. Immunopathology was assessed by changes in numbers, intensity and distribution of stained cells. RESULTS: Parasitised individuals showed villous atrophy and crypt hyperplasia. There was notable infiltration of the lamina propria by IgA positive plasma cells and of the epithelium by intraepithelial lymphocytes. Infection was also associated with increased expression of SC and decreased expression of HLA-DR in epithelial cells. Changes in all parameters correlated with degree of clinical severity. CONCLUSIONS: Profound mucosal changes are induced by strongyloidiasis. Some are analogous to those seen in coeliac disease, but others seem quite unusual. It is likely that these changes are functionally related to the immunopathophysiological consequences of infection seen in patients with severe disease.
Authors: F T Garcia; J T Sessions; W B Strum; E Schweistris; K Tripathy; O Bolaños; H Lotero; E Duque; D Ramelli; L G Mayoral Journal: Am J Trop Med Hyg Date: 1977-09 Impact factor: 2.345
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Authors: H B Coutinho; G King; H F Sewell; P Tighe; V B Coutinho; T I Robalinho; A B Carvalho Journal: Dev Comp Immunol Date: 1993 Nov-Dec Impact factor: 3.636
Authors: Pamela A Knight; Alan D Pemberton; Kevin A Robertson; Douglas J Roy; Steven H Wright; Hugh R P Miller Journal: Infect Immun Date: 2004-10 Impact factor: 3.441
Authors: Luis Malpica; A Clinton White; Cristina Leguia; Natalia Freundt; Nicolas Barros; Cesar Chian; E Antonio Antunez; Martin Montes Journal: PLoS Negl Trop Dis Date: 2019-06-06