Literature DB >> 9037052

Evidence for a role for DNA polymerase beta in mammalian meiosis.

A W Plug1, C A Clairmont, E Sapi, T Ashley, J B Sweasy.   

Abstract

DNA polymerase beta (pol beta) is an enzyme possessing both polymerase and deoxyribose phophatase activities. Although pol beta is not believed to participate in the replication of genomic DNA, several studies have indicated a role for pol beta in DNA repair. The high level of expression of pol beta in mouse and rat testes raises the possibility that pol beta participates in mammalian meiosis. Using antibody localization, we detect foci that stain with pol beta antisera at discrete sites along homologous chromosomes as they synapse and progress through prophase of meiosis I. These data suggest that pol beta participates in meiotic events associated with synapsis and recombination.

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Year:  1997        PMID： 9037052      PMCID： PMC19790          DOI： 10.1073/pnas.94.4.1327

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  39 in total

1.  Changes in the DNA polymerase beta gene expression during development of lung, brain, and testis suggest an involvement of the enzyme in DNA recombination.

Authors:  R Nowak; M Woszczynski; J A Siedlecki
Journal:  Exp Cell Res       Date:  1990-11       Impact factor: 3.905

Review 2.  Chromosome synapsis and genetic recombination: their roles in meiotic chromosome segregation.

Authors:  G S Roeder
Journal:  Trends Genet       Date:  1990-12       Impact factor: 11.639

3.  Sequential initiation of lagging and leading strand synthesis by two different polymerase complexes at the SV40 DNA replication origin.

Authors:  T Tsurimoto; T Melendy; B Stillman
Journal:  Nature       Date:  1990-08-09       Impact factor: 49.962

4.  Requirement for two DNA polymerases in the replication of simian virus 40 DNA in vitro.

Authors:  D H Weinberg; T J Kelly
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

5.  Vectors that facilitate the expression and purification of foreign peptides in Escherichia coli by fusion to maltose-binding protein.

Authors:  C di Guan; P Li; P D Riggs; H Inouye
Journal:  Gene       Date:  1988-07-15       Impact factor: 3.688

6.  Gene conversion, recombination nodules, and the initiation of meiotic synapsis.

Authors:  A T Carpenter
Journal:  Bioessays       Date:  1987-05       Impact factor: 4.345

7.  Meiosis in the foetal mouse ovary. I. An analysis at the light microscope level using surface-spreading.

Authors:  R M Speed
Journal:  Chromosoma       Date:  1982       Impact factor: 4.316

8.  Detection of enzymatic activities in sodium dodecyl sulfate-polyacrylamide gels: DNA polymerases as model enzymes.

Authors:  A Blank; J R Silber; M P Thelen; C A Dekker
Journal:  Anal Biochem       Date:  1983-12       Impact factor: 3.365

9.  Mammalian DNA polymerase beta can substitute for DNA polymerase I during DNA replication in Escherichia coli.

Authors:  J B Sweasy; L A Loeb
Journal:  J Biol Chem       Date:  1992-01-25       Impact factor: 5.157

10.  Synaptonemal complex antigen location and conservation.

Authors:  P B Moens; C Heyting; A J Dietrich; W van Raamsdonk; Q Chen
Journal:  J Cell Biol       Date:  1987-07       Impact factor: 10.539
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  25 in total

1.  Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally.

Authors:  G Esposito; G Texido; U A Betz; H Gu; W Müller; U Klein; K Rajewsky
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-01       Impact factor: 11.205

Review 2.  Meiotic Recombination: The Essence of Heredity.

Authors:  Neil Hunter
Journal:  Cold Spring Harb Perspect Biol       Date:  2015-10-28       Impact factor: 10.005

3.  Clamping down on mammalian meiosis.

Authors:  Amy M Lyndaker; Ana Vasileva; Debra J Wolgemuth; Robert S Weiss; Howard B Lieberman
Journal:  Cell Cycle       Date:  2013-08-26       Impact factor: 4.534

Review 4.  Human female meiosis: new insights into an error-prone process.

Authors:  D Warburton
Journal:  Am J Hum Genet       Date:  1997-07       Impact factor: 11.025

5.  Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.

Authors:  Yosuke Kobayashi; Miho Watanabe; Yuki Okada; Hirofumi Sawa; Hiroyuki Takai; Makoto Nakanishi; Yosuke Kawase; Hiroshi Suzuki; Kazuo Nagashima; Kyoji Ikeda; Noboru Motoyama
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

6.  A variant of DNA polymerase beta acts as a dominant negative mutant.

Authors:  N Bhattacharyya; S Banerjee
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-16       Impact factor: 11.205

Review 7.  Eukaryotic DNA Polymerases in Homologous Recombination.

Authors:  Mitch McVey; Varandt Y Khodaverdian; Damon Meyer; Paula Gonçalves Cerqueira; Wolf-Dietrich Heyer
Journal:  Annu Rev Genet       Date:  2016-11-23       Impact factor: 16.830

8.  DNA substrate dependence of p53-mediated regulation of double-strand break repair.

Authors:  Nuray Akyüz; Gisa S Boehden; Silke Süsse; Andreas Rimek; Ute Preuss; Karl-Heinz Scheidtmann; Lisa Wiesmüller
Journal:  Mol Cell Biol       Date:  2002-09       Impact factor: 4.272

9.  DNA polymerase beta is critical for mouse meiotic synapsis.

Authors:  Dawit Kidane; Alan S Jonason; Timothy S Gorton; Ivailo Mihaylov; Jing Pan; Scott Keeney; Dirk G de Rooij; Terry Ashley; Agnes Keh; Yanfeng Liu; Urmi Banerjee; Daniel Zelterman; Joann B Sweasy
Journal:  EMBO J       Date:  2009-12-17       Impact factor: 11.598

10.  Correlation of meiotic events in testis sections and microspreads of mouse spermatocytes relative to the mid-pachytene checkpoint.

Authors:  Terry Ashley; Ann P Gaeth; Laura B Creemers; Adelle M Hack; Dirk G de Rooij
Journal:  Chromosoma       Date:  2004-07-29       Impact factor: 4.316
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