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Literature DB >> 9035298

Effect of gene therapy with the herpes simplex virus-thymidine kinase gene on hepatic metastasis in murine colon cancer.

S Hayashi¹, N Emi, I Yokoyama, K Uchida, H Takagi.

Abstract

Hepatic metastasis of colon cancer is an important prognostic factor for survival. In this study, we examined the effect of gene therapy using the herpes simplex virus-thymidine kinase (HS-tk) gene with short-course ganciclovir (GCV) treatment for multiple hepatic metastases of murine colon cancer. Colon26 cells transfected with the HS-tk gene were found to be sensitive to GCV in a concentration-dependent way. On the other hand, induction of the HS-tk gene in the cells had no influence on cell growth in vitro. However, multiple hepatic metastases of Colon26 cells transfected with HS-tk gene were significantly suppressed by the GCV treatment. These results thus suggest that HS-tk gene therapy is useful for the treatment of hepatic metastasis in colon cancer.

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Year: 1997 PMID： 9035298 DOI： 10.1007/bf01366937

Source DB: PubMed Journal: Surg Today ISSN： 0941-1291 Impact factor: 2.549

22 in total

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Journal: J Surg Res Date: 1996-02-15 Impact factor: 2.192

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7. The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

Authors: S M Freeman; C N Abboud; K A Whartenby; C H Packman; D S Koeplin; F L Moolten; G N Abraham
Journal: Cancer Res Date: 1993-11-01 Impact factor: 12.701

8. Multiple transduction as a means of preserving ganciclovir chemosensitivity in sarcoma cells carrying retrovirally transduced herpes thymidine kinase genes.

Authors: F S Moolten; J M Wells; P J Mroz
Journal: Cancer Lett Date: 1992-07-10 Impact factor: 8.679