Literature DB >> 9033585

Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 A resolution.

H Rasmussen, J S Kastrup, J N Nielsen, J M Nielsen, P E Nielsen.   

Abstract

The crystal structure of a PNA duplex reveals both a right- and a left-handed helix in the unit cell. The helices are wide (28A), large pitched (18bp) with the base pairs perpendicular to the helix axis, thereby demonstrating that PNA besides adapting to oligonucleotide partners also has a unique structure by itself.

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Year:  1997        PMID: 9033585     DOI: 10.1038/nsb0297-98

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN: 1072-8368


  38 in total

1.  Hydration changes upon DNA folding studied by osmotic stress experiments.

Authors:  Shu-ichi Nakano; Daisuke Yamaguchi; Hisae Tateishi-Karimata; Daisuke Miyoshi; Naoki Sugimoto
Journal:  Biophys J       Date:  2012-06-19       Impact factor: 4.033

2.  Effect of chirality in gamma-PNA: PNA interaction, another piece in the picture.

Authors:  Alex Manicardi; Roberto Corradini
Journal:  Artif DNA PNA XNA       Date:  2014-12-15

3.  Molecular dynamics study of small PNA molecules in lipid-water system.

Authors:  Pawel Weronski; Yi Jiang; Steen Rasmussen
Journal:  Biophys J       Date:  2007-02-16       Impact factor: 4.033

4.  Unique properties of purine/pyrimidine asymmetric PNA.DNA duplexes: differential stabilization of PNA.DNA duplexes by purines in the PNA strand.

Authors:  Anjana Sen; Peter E Nielsen
Journal:  Biophys J       Date:  2005-12-02       Impact factor: 4.033

5.  Question 1: Peptide nucleic acids and the origin and homochirality of life.

Authors:  Peter E Nielsen
Journal:  Orig Life Evol Biosph       Date:  2007-07-17       Impact factor: 1.950

6.  Hybridization energies of double strands composed of DNA, RNA, PNA and LNA.

Authors:  Takayuki Natsume; Yasuyuki Ishikawa; Kenichi Dedachi; Takayuki Tsukamoto; Noriyuki Kurita
Journal:  Chem Phys Lett       Date:  2007-01-26       Impact factor: 2.328

7.  Insights into peptide nucleic acid (PNA) structural features: the crystal structure of a D-lysine-based chiral PNA-DNA duplex.

Authors:  Valeria Menchise; Giuseppina De Simone; Tullia Tedeschi; Roberto Corradini; Stefano Sforza; Rosangela Marchelli; Domenica Capasso; Michele Saviano; Carlo Pedone
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-25       Impact factor: 11.205

8.  Orientation preferences of backbone secondary amide functional groups in peptide nucleic acid complexes: quantum chemical calculations reveal an intrinsic preference of cationic D-amino acid-based chiral PNA analogues for the P-form.

Authors:  Christopher M Topham; Jeremy C Smith
Journal:  Biophys J       Date:  2006-10-27       Impact factor: 4.033

9.  The crystal structure of an 'All Locked' nucleic acid duplex.

Authors:  André Eichert; Katja Behling; Christian Betzel; Volker A Erdmann; Jens P Fürste; Charlotte Förster
Journal:  Nucleic Acids Res       Date:  2010-06-08       Impact factor: 16.971

10.  Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency.

Authors:  Caitriona McLean; Catherine M Greene; Noel G McElvaney
Journal:  Biologics       Date:  2009-07-13
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