Antiphospholipid antibodies in healthy pregnant women.

This article discusses the prevalence and clinical significance of antiphospholipid antibodies (aPL) in the normal, healthy pregnant population. Although an increased risk for adverse fetal outcome has been shown in a small subset of this population, most pregnancies in aPL-positive mothers have successful outcomes. We review the variations in aPL levels during pregnancy and consider screening strategies and therapeutic interventions in healthy aPL-positive pregnant women.