Literature DB >> 9030708

Prodynorphin, proenkephalin and kappa opioid receptor mRNA responses to acute "binge" cocaine.

R Spangler1, Y Zhou, C E Maggos, S D Schlussman, A Ho, M J Kreek.   

Abstract

Previous studies showed that preprodynorphin (ppDyn) mRNA increases in caudate-putamen while kappa opioid receptor (KOR) mRNA decreases in substantia nigra after 3 and 14 days "binge" cocaine. To further characterize opioid mRNA responses, rats were administered: saline; 1 day cocaine followed by 1 day saline; 1 day cocaine; or 2 days cocaine. ppDyn mRNA in caudate-putamen increased in both groups receiving cocaine on the final day compared to groups receiving saline. Preproenkephalin (ppEnk) mRNA in caudate-putamen increased, and KOR mRNA in substantia nigra decreased, after 2 days of cocaine. Thus ppDyn mRNA is elevated acutely by cocaine, while ppEnk and KOR mRNAs show a significant response only on the second day of "binge" cocaine.

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Year:  1997        PMID： 9030708     DOI： 10.1016/s0169-328x(96)00249-5

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


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