OBJECTIVE: To study the possibilities and limitations of postexposure treatment to prevent the establishment of infection after accidental exposure to HIV. DESIGN AND METHODS: The effect of 2,3'-dideoxy-3'-hydroxymethyl cytidine (B1 A-005) was investigated on acute simian immunodeficiency virus (SIV) and HIV-2 infections in macaques in pre- and postexposure treatment experiments. RESULTS: Postexposure treatment with BLA-005 (3 x 10 mg/kg) for as short as 3 days prevented infection with SIVsm after intravenous or rectal inoculation. Infection with HIV-2 could also be blocked by postexposure BFA-005 treatment. CONCLUSION: This study shows that therapeutic intervention can block early systemic and mucosal infections with SIV and HIV-2. Further evaluation is ongoing.
OBJECTIVE: To study the possibilities and limitations of postexposure treatment to prevent the establishment of infection after accidental exposure to HIV. DESIGN AND METHODS: The effect of 2,3'-dideoxy-3'-hydroxymethyl cytidine (B1 A-005) was investigated on acute simian immunodeficiency virus (SIV) and HIV-2 infections in macaques in pre- and postexposure treatment experiments. RESULTS: Postexposure treatment with BLA-005 (3 x 10 mg/kg) for as short as 3 days prevented infection with SIVsm after intravenous or rectal inoculation. Infection with HIV-2 could also be blocked by postexposure BFA-005 treatment. CONCLUSION: This study shows that therapeutic intervention can block early systemic and mucosal infections with SIV and HIV-2. Further evaluation is ongoing.
Authors: R A Otten; D K Smith; D R Adams; J K Pullium; E Jackson; C N Kim; H Jaffe; R Janssen; S Butera; T M Folks Journal: J Virol Date: 2000-10 Impact factor: 5.103
Authors: C Giaquinto; M Penazzato; R Rosso; S Bernardi; O Rampon; P Nasta; A Ammassari; A Antinori; R Badolato; G Castelli Gattinara; A d'Arminio Monforte; M De Martino; A De Rossi; P Di Gregorio; S Esposito; F Fatuzzo; S Fiore; A Franco; C Gabiano; L Galli; O Genovese; V Giacomet; A Giannattasio; C Gotta; A Guarino; A Martino; F Mazzotta; N Principi; M B Regazzi; P Rossi; R Russo; M Saitta; F Salvini; S Trotta; A Viganò; G Zuccotti; G Carosi Journal: Infection Date: 2010-06-01 Impact factor: 7.455