Literature DB >> 9028043

Bone resorption inhibitors from hop extract.

H Tobe1, Y Muraki, K Kitamura, O Komiyama, Y Sato, T Sugioka, H B Maruyama, E Matsuda, M Nagai.   

Abstract

We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humulone as active ingredients. Especially humulone had extraordinarily strong inhibitory activity and the IC50 (concentration of 50% inhibition) value was 5.9 x 10(-9)M.

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Year:  1997        PMID： 9028043     DOI： 10.1271/bbb.61.158

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  9 in total

Review 1.  The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties.

Authors:  L R Chadwick; G F Pauli; N R Farnsworth
Journal:  Phytomedicine       Date:  2005-07-01       Impact factor: 5.340

2.  Optimization of conditions for supercritical fluid extraction of flavonoids from hops (Humulus lupulus L.).

Authors:  Guo-Qing He; Hao-Ping Xiong; Qi-He Chen; Hui Ruan; Zhao-Yue Wang; Lonseny Traoré
Journal:  J Zhejiang Univ Sci B       Date:  2005-10       Impact factor: 3.066

3.  Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.

Authors:  Kuzhuvelil B Harikumar; Ajaikumar B Kunnumakkara; Kwang S Ahn; Preetha Anand; Sunil Krishnan; Sushovan Guha; Bharat B Aggarwal
Journal:  Blood       Date:  2008-10-24       Impact factor: 22.113

4.  Effect of xanthohumol on melanogenesis in B16 melanoma cells.

Authors:  Jeung-Hyun Koo; Hyoung Tae Kim; Ha-Yong Yoon; Kang-Beom Kwon; Il-Whan Choi; Sung Hoo Jung; Han-Uk Kim; Byung-Hyun Park; Jin-Woo Park
Journal:  Exp Mol Med       Date:  2008-06-30       Impact factor: 8.718

5.  Water solution of onion crude powder inhibits RANKL-induced osteoclastogenesis through ERK, p38 and NF-kappaB pathways.

Authors:  C-H Tang; T-H Huang; C-S Chang; W-M Fu; R-S Yang
Journal:  Osteoporos Int       Date:  2008-05-28       Impact factor: 4.507

6.  A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus.

Authors:  Annekathrin M Keiler; Janina Helle; Manuela I Bader; Tino Ehrhardt; Kristin Nestler; Georg Kretzschmar; Ricardo Bernhardt; Günter Vollmer; Dejan Nikolić; Judy L Bolton; Guido F Pauli; Shao-Nong Chen; Birgit M Dietz; Richard B van Breemen; Oliver Zierau
Journal:  Phytomedicine       Date:  2017-08-02       Impact factor: 5.340

Review 7.  Wine, beer, alcohol and polyphenols on cardiovascular disease and cancer.

Authors:  Sara Arranz; Gemma Chiva-Blanch; Palmira Valderas-Martínez; Alex Medina-Remón; Rosa M Lamuela-Raventós; Ramón Estruch
Journal:  Nutrients       Date:  2012-07-10       Impact factor: 6.706

8.  Xanthohumol prevents dextran sulfate sodium-induced colitis via inhibition of IKKβ/NF-κB signaling in mice.

Authors:  Jae-Min Cho; Sun-Mi Yun; Young-Ho Choi; Jinyuk Heo; Nam-Jung Kim; Seok-Ho Kim; Eun-Hee Kim
Journal:  Oncotarget       Date:  2017-12-12

Review 9.  Effects of the Non-Alcoholic Fraction of Beer on Abdominal Fat, Osteoporosis, and Body Hydration in Women.

Authors:  Marta Trius-Soler; Arnau Vilas-Franquesa; Anna Tresserra-Rimbau; Gemma Sasot; Carolina E Storniolo; Ramon Estruch; Rosa M Lamuela-Raventós
Journal:  Molecules       Date:  2020-08-27       Impact factor: 4.411
  9 in total

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