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Literature DB >> 9019395

Somatic mutations in paroxysmal nocturnal hemoglobinuria: a blessing in disguise?

L Luzzatto¹, M Bessler, B Rotoli.

Abstract

Entities: Disease Mutation

Mesh：

Substances：

Year: 1997 PMID： 9019395 DOI： 10.1016/s0092-8674(00)81850-4

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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51 in total

1. Genetic and environmental effects in paroxysmal nocturnal hemoglobinuria: this little PIG-A goes "Why? Why? Why?".

Authors: N S Young; J P Maciejewski
Journal: J Clin Invest Date: 2000-09 Impact factor: 14.808

2. Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals.

Authors: D J Araten; K Nafa; K Pakdeesuwan; L Luzzatto
Journal: Proc Natl Acad Sci U S A Date: 1999-04-27 Impact factor: 11.205

3. Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion.

Authors: V Rosti; G Tremml; V Soares; P P Pandolfi; L Luzzatto; M Bessler
Journal: J Clin Invest Date: 1997-09-01 Impact factor: 14.808

4. The Frequency and Degree of Cosuppression by Sense Chalcone Synthase Transgenes Are Dependent on Transgene Promoter Strength and Are Reduced by Premature Nonsense Codons in the Transgene Coding Sequence.

Authors: Q. Que; H. Y. Wang; J. J. English; R. A. Jorgensen
Journal: Plant Cell Date: 1997-08 Impact factor: 11.277

5. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells.

Authors: Jeffrey J Pu; Rong Hu; Galina L Mukhina; Hetty E Carraway; Michael A McDevitt; Robert A Brodsky
Journal: Haematologica Date: 2012-02-07 Impact factor: 9.941

Somatic mutations in paroxysmal nocturnal hemoglobinuria: a blessing in disguise?

1. Genetic and environmental effects in paroxysmal nocturnal hemoglobinuria: this little PIG-A goes "Why? Why? Why?".

2. Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals.

3. Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion.

4. The Frequency and Degree of Cosuppression by Sense Chalcone Synthase Transgenes Are Dependent on Transgene Promoter Strength and Are Reduced by Premature Nonsense Codons in the Transgene Coding Sequence.

5. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells.

6. Some dynamic aspects of hematopoietic stem cells.

Review 7. Expanding Complement Therapeutics for the Treatment of Paroxysmal Nocturnal Hemoglobinuria.

Review 8. Paroxysmal nocturnal haemoglobinuria.

9. On the dynamics of neutral mutations in a mathematical model for a homogeneous stem cell population.

Review 10. Secretory leukoprotease inhibitor: a native antimicrobial protein presenting a new therapeutic option?