F Arias1, A Victoria, K Cho, F Kraus. 1. Department of Obstetrics and Gynecology, St. John's Mercy Medical Center, St. Louis, Missouri, USA.
Abstract
OBJECTIVE: To analyze the placental histology in cases of preterm premature rupture of membranes (PROM), classify the cases according to the results of the histologic examination, and determine if these histologic groups have different clinical characteristics and outcomes. METHODS: During a 3-year period, a cohort of 235 women with preterm PROM was studied prospectively. The women were classified according to placental histologic findings, and their prenatal and intrapartum courses and perinatal mortality and morbidity were analyzed and compared. RESULTS: One hundred two placentas (43.4%) exhibited acute inflammatory lesions, 48 (20.4%) had vascular lesions, 48 (20.4%) had both inflammatory and vascular lesions, 31 (13.2%) had no abnormal findings, four (1.7%) had villous edema, and two (0.8%) had chronic villitis. The four largest histologic groups had distinctive characteristics with respect to gestational age at the time of PROM and at delivery, duration of the latency period, and perinatal mortality and morbidity. CONCLUSION: Cases of preterm PROM may be classified according to placental histologic findings, and these groups have different clinical manifestations, prognoses, and outcomes.
OBJECTIVE: To analyze the placental histology in cases of preterm premature rupture of membranes (PROM), classify the cases according to the results of the histologic examination, and determine if these histologic groups have different clinical characteristics and outcomes. METHODS: During a 3-year period, a cohort of 235 women with preterm PROM was studied prospectively. The women were classified according to placental histologic findings, and their prenatal and intrapartum courses and perinatal mortality and morbidity were analyzed and compared. RESULTS: One hundred two placentas (43.4%) exhibited acute inflammatory lesions, 48 (20.4%) had vascular lesions, 48 (20.4%) had both inflammatory and vascular lesions, 31 (13.2%) had no abnormal findings, four (1.7%) had villous edema, and two (0.8%) had chronic villitis. The four largest histologic groups had distinctive characteristics with respect to gestational age at the time of PROM and at delivery, duration of the latency period, and perinatal mortality and morbidity. CONCLUSION: Cases of preterm PROM may be classified according to placental histologic findings, and these groups have different clinical manifestations, prognoses, and outcomes.
Authors: Roberto Romero; Juan Pedro Kusanovic; Hernan Muñoz; Ricardo Gomez; Ronald F Lamont; Lami Yeo Journal: J Matern Fetal Neonatal Med Date: 2010-04
Authors: Roberto Romero; Juan Pedro Kusanovic; Ricardo Gomez; Ronald Lamont; Egle Bytautiene; Robert E Garfield; Pooja Mittal; Sonia S Hassan; Lami Yeo Journal: J Matern Fetal Neonatal Med Date: 2010-04
Authors: Chong Jai Kim; Roberto Romero; Juan Pedro Kusanovic; Wonsuk Yoo; Zhong Dong; Vanessa Topping; Francesca Gotsch; Bo Hyun Yoon; Je Geun Chi; Jung-Sun Kim Journal: Mod Pathol Date: 2010-03-26 Impact factor: 7.842
Authors: Roberto Romero; Lara A Friel; Digna R Velez Edwards; Juan Pedro Kusanovic; Sonia S Hassan; Shali Mazaki-Tovi; Edi Vaisbuch; Chong Jai Kim; Offer Erez; Tinnakorn Chaiworapongsa; Brad D Pearce; Jacquelaine Bartlett; Benjamin A Salisbury; Madan Kumar Anant; Gerald F Vovis; Min Seob Lee; Ricardo Gomez; Ernesto Behnke; Enrique Oyarzun; Gerard Tromp; Scott M Williams; Ramkumar Menon Journal: Am J Obstet Gynecol Date: 2010-07-31 Impact factor: 8.661