| Literature DB >> 9012862 |
R M Hudziak1, E Barofsky, D F Barofsky, D L Weller, S B Huang, D D Weller.
Abstract
Oligomers possessing the Morpholino phosphorodiamidate backbone were evaluated for resistance to a variety of enzymes and biologic fluids. A 25-mer was incubated with nucleases, proteases, esterases, and serum, and the reaction mixtures were directly analyzed by MALDI-TOF mass spectrometry. The 25-mer was completely resistant to 13 different hydrolases and serum and plasma. The excellent resistance of Morpholino phosphorodiamidates to enzymatic attack indicates their suitability for in vivo use.Entities:
Mesh：
Substances：
Year: 1996 PMID： 9012862 DOI： 10.1089/oli.1.1996.6.267
Source DB: PubMed Journal: Antisense Nucleic Acid Drug Dev ISSN： 1087-2906