Literature DB >> 9009349

Porphyromonas gingivalis fimbria-stimulated bone resorption is inhibited through binding of the fimbriae to fibronectin.

Y Kawata1, H Iwasaka, S Kitano, S Hanazawa.   

Abstract

Our most recent study demonstrated that fibronectin is one of the Porphyromonas gingivalis fimbria-binding proteins. In this present study, we demonstrate with mouse embryonic calvarial cells that P. gingivalis fimbria-stimulated bone resorption is inhibited by human fibronectin. The fibronectin inhibition was dose and culture time dependent and was completely neutralized by antifibronectin antibody. The inhibitory action of fibronectin depended on fimbrial interaction with the heparin-binding and cell-attachment domains in the fibronectin structure.

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Year:  1997        PMID： 9009349      PMCID： PMC176132          DOI： 10.1128/iai.65.2.815-817.1997

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  23 in total

1.  Three types of binding by Porphyromonas gingivalis and oral bacteria to fibronectin, buccal epithelial cells and erythrocytes.

Authors:  E Isogai; K Hirose; N Fujii; H Isogai
Journal:  Arch Oral Biol       Date:  1992-08       Impact factor: 2.633

2.  An assay system utilizing devitalized bone for assessment of differentiation of osteoclast progenitors.

Authors:  S Amano; S Hanazawa; Y Kawata; K Ohta; H Kitami; S Kitano
Journal:  J Bone Miner Res       Date:  1992-03       Impact factor: 6.741

3.  Binding of collagens to an enterotoxigenic strain of Escherichia coli.

Authors:  L Visai; P Speziale; S Bozzini
Journal:  Infect Immun       Date:  1990-02       Impact factor: 3.441

4.  Fibronectin, vitronectin, and collagen binding to Escherichia coli of intestinal and extraintestinal origin.

Authors:  A Ljungh; L Emödy; H Steinruck; P Sullivan; B West; E Zetterberg; T Wadström
Journal:  Zentralbl Bakteriol       Date:  1990-10

5.  Immunization with Porphyromonas (Bacteroides) gingivalis fimbriae protects against periodontal destruction.

Authors:  R T Evans; B Klausen; H T Sojar; G S Bedi; C Sfintescu; N S Ramamurthy; L M Golub; R J Genco
Journal:  Infect Immun       Date:  1992-07       Impact factor: 3.441

6.  Fibronectin-binding protein of Streptococcus pyogenes: sequence of the binding domain involved in adherence of streptococci to epithelial cells.

Authors:  S R Talay; P Valentin-Weigand; P G Jerlström; K N Timmis; G S Chhatwal
Journal:  Infect Immun       Date:  1992-09       Impact factor: 3.441

7.  Basement membrane carbohydrate as a target for bacterial adhesion: binding of type I fimbriae of Salmonella enterica and Escherichia coli to laminin.

Authors:  M Kukkonen; T Raunio; R Virkola; K Lähteenmäki; P H Mäkelä; P Klemm; S Clegg; T K Korhonen
Journal:  Mol Microbiol       Date:  1993-01       Impact factor: 3.501

8.  Porphyromonas gingivalis fimbriae induce expression of the neutrophil chemotactic factor KC gene of mouse peritoneal macrophages: role of protein kinase C.

Authors:  S Hanazawa; Y Murakami; A Takeshita; H Kitami; K Ohta; S Amano; S Kitano
Journal:  Infect Immun       Date:  1992-04       Impact factor: 3.441

9.  Identification of Porphyromonas gingivalis components that mediate its interactions with fibronectin.

Authors:  M S Lantz; R D Allen; L W Duck; J L Blume; L M Switalski; M Hook
Journal:  J Bacteriol       Date:  1991-07       Impact factor: 3.490

10.  Immunization with fimbrial protein and peptide protects against Porphyromonas gingivalis-induced periodontal tissue destruction.

Authors:  R T Evans; B Klausen; R J Genco
Journal:  Adv Exp Med Biol       Date:  1992       Impact factor: 2.622
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  5 in total

1.  Porphyromonas gingivalis fimbriae use beta2 integrin (CD11/CD18) on mouse peritoneal macrophages as a cellular receptor, and the CD18 beta chain plays a functional role in fimbrial signaling.

Authors:  A Takeshita; Y Murakami; Y Yamashita; M Ishida; S Fujisawa; S Kitano; S Hanazawa
Journal:  Infect Immun       Date:  1998-09       Impact factor: 3.441

2.  Clathrin-dependent entry of a gingipain adhesin peptide and Porphyromonas gingivalis into host cells.

Authors:  Heike Boisvert; Margaret J Duncan
Journal:  Cell Microbiol       Date:  2008-08-20       Impact factor: 3.715

3.  Transglutaminase 2 is essential for adherence of Porphyromonas gingivalis to host cells.

Authors:  Heike Boisvert; Laszlo Lorand; Margaret J Duncan
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-24       Impact factor: 11.205

4.  Porphyromonas gingivalis Fimbria-Induced Expression of Inflammatory Cytokines and Cyclooxygenase-2 in Mouse Macrophages and Its Inhibition by the Bioactive Compounds Fibronectin and Melatonin.

Authors:  Yukio Murakami; Mamoru Machino; Seiichiro Fujisawa
Journal:  ISRN Dent       Date:  2012-04-01

Review 5.  Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis.

Authors:  R J Lamont; H F Jenkinson
Journal:  Microbiol Mol Biol Rev       Date:  1998-12       Impact factor: 11.056
  5 in total

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