Literature DB >> 9007998

SAM as a protein interaction domain involved in developmental regulation.

J Schultz1, C P Ponting, K Hofmann, P Bork.   

Abstract

More than 60 previously undetected SAM domain-containing proteins have been identified using profile searching methods. Among these are over 40 EPH-related receptor tyrosine kinases (RPTK), Drosophila bicaudal-C, a p53 from Loligo forbesi, and diacyglycerol-kinase isoform delta. This extended dataset suggests that SAM is an evolutionary conserved protein binding domain that is involved in the regulation of numerous developmental processes among diverse eukaryotes. A conserved tyrosine in the SAM sequences of the EPH related RPTKs is likely to mediate cell-cell initiated signal transduction via the binding of SH2 containing proteins to phosphotyrosine.

Entities:  

Mesh：

Year:  1997        PMID： 9007998      PMCID： PMC2143507          DOI： 10.1002/pro.5560060128

Source DB:  PubMed          Journal:  Protein Sci        ISSN： 0961-8368            Impact factor:   6.725


  29 in total

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Review 3.  Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons.

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Journal:  Cancer Res       Date:  1994-07-15       Impact factor: 12.701

7.  Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.

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8.  The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb.

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Journal:  Genes Dev       Date:  1992-02       Impact factor: 11.361

9.  Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms.

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Journal:  Mol Biol Cell       Date:  1993-01       Impact factor: 4.138

Review 10.  eph, the largest known family of putative growth factor receptors.

Authors:  N L Tuzi; W J Gullick
Journal:  Br J Cancer       Date:  1994-03       Impact factor: 7.640
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  89 in total

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Journal:  Protein Sci       Date:  1999-10       Impact factor: 6.725

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Authors:  Christine Wasylyk; Sophie E Schlumberger; Paola Criqui-Filipe; Bohdan Wasylyk
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Authors:  C A Kim; M L Phillips; W Kim; M Gingery; H H Tran; M A Robinson; S Faham; J U Bowie
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8.  Transcriptional activities of p73 splicing variants are regulated by inter-variant association.

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Journal:  Biochem J       Date:  2001-06-15       Impact factor: 3.857

9.  The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations.

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10.  Identification of a family of animal sphingomyelin synthases.

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