Literature DB >> 9005856

Positive selection of T cells induced by viral delivery of neopeptides to the thymus.

N Nakano1, R Rooke, C Benoist, D Mathis.   

Abstract

The relation between an antigenic peptide that can stimulate a mature T cell and the natural peptide that promoted selection of this cell in the thymus is still unknown. An experimental system was devised to address this issue in vivo-mice expressing neopeptides in thymic stromal cells after adenovirus-mediated delivery of invariant chain-peptide fusion proteins. In this system, selection of T cells capable of responding to a given antigenic peptide could be promoted by the peptide itself, by closely related analogs lacking agonist and antagonist activity, or by ostensibly unrelated peptides. However, the precise repertoire of T cells selected was dictated by the particular neopeptide expressed.

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Year:  1997        PMID： 9005856     DOI： 10.1126/science.275.5300.678

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  30 in total

1.  Introducing endogenous antigens into the major histocompatibility complex (MHC) class II presentation pathway. Both Ii mediated inhibition and enhancement of endogenous peptide/MHC class II presentation require the same Ii domains.

Authors:  K Frauwirth; N Shastri
Journal:  Immunology       Date:  2001-04       Impact factor: 7.397

2.  Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact.

Authors:  Y Fukui; T Oono; J P Cabaniols; K Nakao; K Hirokawa; A Inayoshi; T Sanui; J Kanellopoulos; E Iwata; M Noda; M Katsuki; P Kourilsky; T Sasazuki
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

Review 3.  Review article: thymus organ cultures and T-cell receptor repertoire development.

Authors:  G Anderson; E J Jenkinson
Journal:  Immunology       Date:  2000-08       Impact factor: 7.397

4.  Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection.

Authors:  Christophe Viret; Xin He; Charles A Janeway
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-16       Impact factor: 11.205

Review 5.  The Tritope Model for restrictive recognition of antigen by T-cells II. Implications for ontogeny, evolution and physiology.

Authors:  Melvin Cohn
Journal:  Mol Immunol       Date:  2007-09-21       Impact factor: 4.407

6.  Efficient loading of HLA-DR with a T helper epitope by genetic exchange of CLIP.

Authors:  J van Bergen; S P Schoenberger; F Verreck; R Amons; R Offringa; F Koning
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-08       Impact factor: 11.205

7.  Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes.

Authors:  S Tourne; T Miyazaki; P Wolf; H Ploegh; C Benoist; D Mathis
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-19       Impact factor: 11.205

8.  Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide.

Authors:  C Viret; X He; C A Janeway
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-24       Impact factor: 11.205

9.  On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells.

Authors:  R M Zinkernagel; A Althage
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

10.  Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands.

Authors:  Y Ghendler; M K Teng; J H Liu; T Witte; J Liu; K S Kim; P Kern; H C Chang; J H Wang; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205
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