Literature DB >> 9003798

Siroheme biosynthesis in Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes.

J Hansen1, M Muldbjerg, H Chérest, Y Surdin-Kerjan.   

Abstract

Siroheme is a uroporphyrinogen III-derivative used by sulfite reductase as a prosthetic group. We investigated in Saccharomyces cerevisiae the possible involvement in siroheme biosynthesis of three genes, MET1, MET8 and MET20. The MET1 gene from S. cerevisiae was cloned and shown to be the same gene as MET20. Sequence similitudes as well as complementation studies indicate that Met1p and Met8p are both involved in siroheme biosynthesis. In addition, we show formally that S. cerevisiae does not need vitamin B12 for growth.

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Year:  1997        PMID： 9003798     DOI： 10.1016/s0014-5793(96)01423-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase.

Authors:  Heidi L Schubert; Evelyne Raux; Amanda A Brindley; Helen K Leech; Keith S Wilson; Christopher P Hill; Martin J Warren
Journal:  EMBO J       Date:  2002-05-01       Impact factor: 11.598

2.  Effect of mutations in the transmethylase and dehydrogenase/chelatase domains of sirohaem synthase (CysG) on sirohaem and cobalamin biosynthesis.

Authors:  S C Woodcock; E Raux; F Levillayer; C Thermes; A Rambach; M J Warren
Journal:  Biochem J       Date:  1998-02-15       Impact factor: 3.857

3.  The role of Saccharomyces cerevisiae Met1p and Met8p in sirohaem and cobalamin biosynthesis.

Authors:  E Raux; T McVeigh; S E Peters; T Leustek; M J Warren
Journal:  Biochem J       Date:  1999-03-15       Impact factor: 3.857

Review 4.  Metabolism of sulfur amino acids in Saccharomyces cerevisiae.

Authors:  D Thomas; Y Surdin-Kerjan
Journal:  Microbiol Mol Biol Rev       Date:  1997-12       Impact factor: 11.056

5.  A cysG mutant strain of Rhizobium etli pleiotropically defective in sulfate and nitrate assimilation.

Authors:  R Tate; A Riccio; M Iaccarino; E J Patriarca
Journal:  J Bacteriol       Date:  1997-12       Impact factor: 3.490

6.  Role of heme in the antifungal activity of the azaoxoaporphine alkaloid sampangine.

Authors:  Ameeta K Agarwal; Tao Xu; Melissa R Jacob; Qin Feng; Michael C Lorenz; Larry A Walker; Alice M Clark
Journal:  Eukaryot Cell       Date:  2007-12-21

7.  Structure and function of SirC from Bacillus megaterium: a metal-binding precorrin-2 dehydrogenase.

Authors:  Heidi L Schubert; Ruth S Rose; Helen K Leech; Amanda A Brindley; Christopher P Hill; Stephen E J Rigby; Martin J Warren
Journal:  Biochem J       Date:  2008-10-15       Impact factor: 3.857

Review 8.  Trafficking of heme and porphyrins in metazoa.

Authors:  Scott Severance; Iqbal Hamza
Journal:  Chem Rev       Date:  2009-10       Impact factor: 60.622

9.  Subcellular localization of two types of ferrochelatase in cucumber.

Authors:  T Masuda; T Suzuki; H Shimada; H Ohta; K Takamiya
Journal:  Planta       Date:  2003-03-22       Impact factor: 4.116

10.  Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome.

Authors:  Tomasz Wlodarski; Jan Kutner; Joanna Towpik; Lukasz Knizewski; Leszek Rychlewski; Andrzej Kudlicki; Maga Rowicka; Andrzej Dziembowski; Krzysztof Ginalski
Journal:  PLoS One       Date:  2011-08-09       Impact factor: 3.240
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