| Literature DB >> 9002042 |
M A Shaw1, D Clayton, J M Blackwell.
Abstract
Maximum likelihood identity-by-descent (IBD) sib pair analysis using a 3 locus haplotype NRAMP1-IL8RB-VIL1, or NRAMP1 alone, provided preliminary evidence (maximum LOD score = 1.01, p = 0.024) for a gene in this region of human chromosome 2q35 contributing to susceptibility to rheumatoid arthritis (RA). Candidacy for NRAMP1 as the disease susceptibility gene was supported by a significant bias (p < 0.048) toward transmission of the NRAMP1 promoter region allele 3 in affected offspring.Entities:
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Year: 1997 PMID： 9002042
Source DB: PubMed Journal: J Rheumatol ISSN： 0315-162X Impact factor: 4.666