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Literature DB >> 9000255

Does ibuprofen affect bilirubin-albumin binding in newborn infant serum?

C Cooper-Peel¹, R Brodersen, A Robertson.

Abstract

Intravenous ibuprofen is being studied in sick, premature infants for the prevention of intraventricular haemorrhage and closure of the ductus arteriosus. We tested the effect of ibuprofen on bilirubin-albumin binding in adult and newborn infant serum by measuring the free ibuprofen concentration in the presence of bilirubin (reverse displacement method). At clinically appropriate ibuprofen concentrations the free fraction of bilirubin is increased by a factor of 4. Ibuprofen may increase the risk of bilirubin encephalopathy when used in sick, premature infants.

Entities: Chemical Disease Species

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Year: 1996 PMID： 9000255 DOI： 10.1111/j.1600-0773.1996.tb00012.x

Source DB: PubMed Journal: Pharmacol Toxicol ISSN： 0901-9928

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Cited

13 in total

Review 1. Patent ductus arteriousus in the premature neonate: current concepts in pharmacological management.

Authors: C Hammerman; M Kaplan
Journal: Paediatr Drugs Date: 1999 Apr-Jun Impact factor: 3.022

2. Ibuprofen for closure of patent ductus arteriosus: is it really safe in hyperbilirubinaemic infants?

Authors: Thor Willy Ruud Hansen
Journal: Eur J Pediatr Date: 2003-02-27 Impact factor: 3.183

3. Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease.

Authors: Kevin A Strauss; Donna L Robinson; Hendrik J Vreman; Erik G Puffenberger; Graham Hart; D Holmes Morton
Journal: Eur J Pediatr Date: 2006-01-25 Impact factor: 3.183

4. Clinical considerations for the pharmacologic management of patent ductus arteriosus with cyclooxygenase inhibitors in premature infants.

Authors: Karen E Corff; Kris C Sekar
Journal: J Pediatr Pharmacol Ther Date: 2007-07

Does ibuprofen affect bilirubin-albumin binding in newborn infant serum?

Review 1. Patent ductus arteriousus in the premature neonate: current concepts in pharmacological management.

2. Ibuprofen for closure of patent ductus arteriosus: is it really safe in hyperbilirubinaemic infants?

3. Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease.

4. Clinical considerations for the pharmacologic management of patent ductus arteriosus with cyclooxygenase inhibitors in premature infants.

5. Pharmacologic, pharmacodynamic, and pharmacokinetic considerations with intravenous Ibuprofen lysine.

Review 6. Bilirubin Binding Capacity in the Preterm Neonate.

Review 7. Oral medications regarding their safety and efficacy in the management of patent ductus arteriosus.

Review 8. Clinical pharmacokinetics of ibuprofen. The first 30 years.

9. Effect of ibuprofen on bilirubin-albumin binding affinity in premature infants.

Review 10. Nonsteroidal anti-inflammatory agents in neonates.