PURPOSE: We attempted to determine the tissue of origin of tumors after augmentation enterocystoplasty. MATERIALS AND METHODS: We retrospectively reviewed the histological findings of 4 tumors that developed after clam ileocystoplasty. RESULTS: Tumors were primarily adenocarcinoma that originated on the bladder side of the anastomosis. The urothelium showed glandular metaplasia and dysplasia with intestinalization overlying normal detrusor muscle. These changes were also present in the renal pelvis in 1 patient with ureteral reflux. Bowel mucosa was normal except for inflammation. CONCLUSIONS: These tumors are derived from urothelium, which may be due to elevated urinary nitrosamines in this group of patients.
PURPOSE: We attempted to determine the tissue of origin of tumors after augmentation enterocystoplasty. MATERIALS AND METHODS: We retrospectively reviewed the histological findings of 4 tumors that developed after clam ileocystoplasty. RESULTS:Tumors were primarily adenocarcinoma that originated on the bladder side of the anastomosis. The urothelium showed glandular metaplasia and dysplasia with intestinalization overlying normal detrusor muscle. These changes were also present in the renal pelvis in 1 patient with ureteral reflux. Bowel mucosa was normal except for inflammation. CONCLUSIONS: These tumors are derived from urothelium, which may be due to elevated urinary nitrosamines in this group of patients.