Literature DB >> 8995527

Oxidative-stress associated parameters (lactoferrin, superoxide dismutases) in serum of patients with Alzheimer's disease.

J Thome1, W Gsell, M Rösler, J Kornhuber, L Frölich, E Hashimoto, B Zielke, G A Wiesbeck, P Riederer.   

Abstract

In this case/control study, serum levels of oxidative stress related parameters such as Fe-binding lactoferrin (LTF), Mn- and Zn,Cu-superoxide dismutase (SOD) were determined by enzyme linked immunoassays in patients suffering from the Alzheimer's dementia as well as in non-demented controls. The Mn-SOD concentration was significantly (P<0.05, U-test) reduced in patients suffering from Alzheimer's disease if compared to non-demented controls. The other parameters investigated did not differ significantly between both groups. Our findings give evidence for the hypothesis of a disturbed free radical metabolism in Alzheimer's disease. The specificity of these results remains to be clarified. Further studies are needed to elucidate the relevance of oxidative stress in the etiopathogenesis of the Alzheimer's disease.

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Year:  1997        PMID： 8995527     DOI： 10.1016/s0024-3205(96)00583-8

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  10 in total

1.  Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administration.

Authors:  Elsa M Janle; Mary Ann Lila; Michael Grannan; Lauren Wood; Aine Higgins; Gad G Yousef; Randy B Rogers; Helen Kim; George S Jackson; Lap Ho; Connie M Weaver
Journal:  J Med Food       Date:  2010-08       Impact factor: 2.786

2.  Intake of flavonoids and risk of dementia.

Authors:  D Commenges; V Scotet; S Renaud; H Jacqmin-Gadda; P Barberger-Gateau; J F Dartigues
Journal:  Eur J Epidemiol       Date:  2000-04       Impact factor: 8.082

3.  The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defense.

Authors:  E Karelson; N Bogdanovic; A Garlind; B Winblad; K Zilmer; T Kullisaar; T Vihalemm; C Kairane; M Zilmer
Journal:  Neurochem Res       Date:  2001-04       Impact factor: 3.996

4.  Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease.

Authors:  Ana Knezovic; Jelena Osmanovic-Barilar; Marija Curlin; Patrick R Hof; Goran Simic; Peter Riederer; Melita Salkovic-Petrisic
Journal:  J Neural Transm (Vienna)       Date:  2015-03-26       Impact factor: 3.575

5.  Candidate genes for the progression of malignant gliomas identified by microarray analysis.

Authors:  Oliver Bozinov; Sylvia Köhler; Birgit Samans; Ludwig Benes; Dorothea Miller; Markus Ritter; Ulrich Sure; Helmut Bertalanffy
Journal:  Neurosurg Rev       Date:  2007-10-05       Impact factor: 3.042

Review 6.  Plant Foods Rich in Antioxidants and Human Cognition: A Systematic Review.

Authors:  Luciana Baroni; Anna Rita Sarni; Cristina Zuliani
Journal:  Antioxidants (Basel)       Date:  2021-04-30

7.  Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer's disease.

Authors:  Priscilla Youssef; Belal Chami; Julia Lim; Terry Middleton; Greg T Sutherland; Paul K Witting
Journal:  Sci Rep       Date:  2018-08-01       Impact factor: 4.379

8.  Evaluation of the Anti-Inflammatory and Anti-Oxidative Effects of Therapeutic Human Lactoferrin Fragments.

Authors:  Yu Pan; Zhao Liu; Yijie Wang; Linshen Zhang; Niying Chua; Lei Dai; Jun Chen; Chun Loong Ho
Journal:  Front Bioeng Biotechnol       Date:  2021-11-30

Review 9.  Salivary biomarkers for the diagnosis and monitoring of neurological diseases.

Authors:  Raymond Farah; Hayat Haraty; Ziad Salame; Youssef Fares; David M Ojcius; Najwane Said Sadier
Journal:  Biomed J       Date:  2018-05-10       Impact factor: 4.910

10.  The Analysis of Oxidative Stress Markers May Increase the Accuracy of the Differential Diagnosis of Alzheimer's Disease with and without Depression.

Authors:  Anna Polak-Szabela; Inga Dziembowska; Marietta Bracha; Agnieszka Pedrycz-Wieczorska; Kornelia Kedziora-Kornatowska; Mariusz Kozakiewicz
Journal:  Clin Interv Aging       Date:  2021-06-16       Impact factor: 4.458
  10 in total

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