Literature DB >> 8991957

Squamotacin: an annonaceous acetogenin with cytotoxic selectivity for the human prostate tumor cell line (PC-3).

D C Hopp1, L Zeng, Z Gu, J L McLaughlin.   

Abstract

The bark extracts of Annona squamosa yielded a new bioactive acetogenin, squamotacin (1), and the known compound, molvizarin (2), which is new to this species. Compound 1 is identical to the potent acetogenin, bullatacin (3), except that the adjacent bistetrahydrofuran (THF) rings and their flanking hydroxyls are shifted two carbons toward the gamma-lactone ring. Compound 1 showed cytotoxic selectively for the human prostate tumor cell line (PC-3), with a potency of over 100 million times that of Adriamycin.

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Year:  1996        PMID： 8991957     DOI： 10.1021/np960124i

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  5 in total

1.  Antiproliferative acetogenins from a Uvaria sp. from the Madagascar dry forest.

Authors:  Yumin Dai; Liva Harinantenaina; Peggy J Brodie; Martin W Callmander; Richard Randrianaivo; Stephan Rakotonandrasana; Etienne Rakotobe; Vincent E Rasamison; Yongchun Shen; Karen TenDyke; Edward M Suh; David G I Kingston
Journal:  J Nat Prod       Date:  2011-12-02       Impact factor: 4.050

2.  In vitro biological screening of the stem of Desmodium elegans.

Authors:  Arshad Khan; Rabia Usman; Abdur Rauf; Ming-Liang Wang; Naveed Muhammad; Akhatar Aman; Taha Hussein Musa Tahir
Journal:  Asian Pac J Trop Biomed       Date:  2013-09

3.  Anti genotoxic effect of Mosinone-A on 7, 12-dimethyl benz[a] anthracene induced genotoxicity in male golden Syrian hamsters.

Authors:  Govindasamy Sugunadevi; Kathiresan Suresh; Mariadoss Arokia Vijayaanand; Kasinathan Rajalingam; Jagadeesan Sathiyapriya
Journal:  Pathol Oncol Res       Date:  2011-06-25       Impact factor: 3.201

4.  Synthesis and anti-tumor activity of carbohydrate analogues of the tetrahydrofuran containing acetogenins.

Authors:  Stewart Bachan; K A Tony; Akira Kawamura; Diego Montenegro; Anjali Joshi; Himanshu Garg; David R Mootoo
Journal:  Bioorg Med Chem       Date:  2013-08-29       Impact factor: 3.641

5.  Recent progress on the total synthesis of acetogenins from Annonaceae.

Authors:  Nianguang Li; Zhihao Shi; Yuping Tang; Jianwei Chen; Xiang Li
Journal:  Beilstein J Org Chem       Date:  2008-12-05       Impact factor: 2.883
  5 in total

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