| Literature DB >> 8985423 |
J Smyth1, M Suomalainen, H Garoff.
Abstract
Using the Semliki Forest virus (SFV) and Sindbis virus (SIN) cDNAs we have constructed recombinants in which the spike genes were exchanged. Analyses of expression showed that the SFV/SIN(spike) RNA directed efficient assembly of infectious virus, whereas the reciprocal SIN/SFV(spike) RNA was completely unable to assemble virus. This was apparently due to a defective capsid-spike interaction.Entities:
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Year: 1997 PMID: 8985423 PMCID: PMC191124
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103