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Literature DB >> 8985420

Infection of primary cultures of human neural cells by human coronaviruses 229E and OC43.

A Bonavia¹, N Arbour, V W Yong, P J Talbot.

Abstract

We evaluated the ability of human coronaviruses to infect primary cultures of human neural cells. Double immunofluorescence with antibodies to virus and cell markers showed infection of fetal astrocytes and of adult microglia and astrocytes by strain OC43. RNA amplification revealed infection of fetal astrocytes, adult microglia, and a mixed culture of adult oligodendrocytes and astrocytes by strain 229E. Infectious virus was released only from fetal astrocytes, with higher titers for OC43. Human coronaviruses have the capacity to infect some cells of the central nervous system, although infection of adult cells appears abortive.

Entities: Disease Species

Mesh：

Substances：
Antigens, Viral

Year: 1997 PMID： 8985420 PMCID： PMC191121

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

24 in total

1. Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients.

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Journal: J Virol Date: 1985-03 Impact factor: 5.103

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Journal: J Gen Virol Date: 1992-10 Impact factor: 3.891

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Journal: Glia Date: 1992 Impact factor: 7.452

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Authors: N Sharpless; D Gilbert; B Vandercam; J M Zhou; E Verdin; G Ronnett; E Friedman; M Dubois-Dalcq
Journal: Virology Date: 1992-12 Impact factor: 3.616

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Authors: J N Stewart; S Mounir; P J Talbot
Journal: Virology Date: 1992-11 Impact factor: 3.616

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Authors: R S Murray; B Brown; D Brian; G F Cabirac
Journal: Ann Neurol Date: 1992-05 Impact factor: 10.422

9. Coronaviruses SD and SK share extensive nucleotide homology with murine coronavirus MHV-A59, more than that shared between human and murine coronaviruses.

Authors: S R Weiss
Journal: Virology Date: 1983-04-30 Impact factor: 3.616

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Authors: C L Yeager; R A Ashmun; R K Williams; C B Cardellichio; L H Shapiro; A T Look; K V Holmes
Journal: Nature Date: 1992-06-04 Impact factor: 49.962

47 in total

1. Glutamate excitotoxicity is involved in the induction of paralysis in mice after infection by a human coronavirus with a single point mutation in its spike protein.

Authors: Elodie Brison; Hélène Jacomy; Marc Desforges; Pierre J Talbot
Journal: J Virol Date: 2011-09-28 Impact factor: 5.103

2. Titration of human coronaviruses, HcoV-229E and HCoV-OC43, by an indirect immunoperoxidase assay.

Authors: Francine Lambert; Hélène Jacomy; Gabriel Marceau; Pierre J Talbot
Journal: Methods Mol Biol Date: 2008

3. Human coronavirus-induced neuronal programmed cell death is cyclophilin d dependent and potentially caspase dispensable.

Authors: Dominique J Favreau; Mathieu Meessen-Pinard; Marc Desforges; Pierre J Talbot
Journal: J Virol Date: 2011-10-19 Impact factor: 5.103

Infection of primary cultures of human neural cells by human coronaviruses 229E and OC43.

1. Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients.

2. Differential susceptibility of cultured neural cells to the human coronavirus OC43.

3. Sequence analysis of the membrane protein gene of human coronavirus OC43 and evidence for O-glycosylation.

4. Differential proliferative response of human and mouse astrocytes to gamma-interferon.

5. The restricted nature of HIV-1 tropism for cultured neural cells.

6. Human coronavirus gene expression in the brains of multiple sclerosis patients.

7. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

8. Detection of coronavirus RNA and antigen in multiple sclerosis brain.

9. Coronaviruses SD and SK share extensive nucleotide homology with murine coronavirus MHV-A59, more than that shared between human and murine coronaviruses.

10. Human aminopeptidase N is a receptor for human coronavirus 229E.

1. Glutamate excitotoxicity is involved in the induction of paralysis in mice after infection by a human coronavirus with a single point mutation in its spike protein.

2. Titration of human coronaviruses, HcoV-229E and HCoV-OC43, by an indirect immunoperoxidase assay.

3. Human coronavirus-induced neuronal programmed cell death is cyclophilin d dependent and potentially caspase dispensable.

4. In vitro detection of apoptosis in monocytes/macrophages infected with human coronavirus.

5. HCoV-229E infects and activates monocytes.

6. A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes.

7. Neuroinvasion by human respiratory coronaviruses.

8. Human respiratory coronavirus OC43: genetic stability and neuroinvasion.

9. Involvement of aminopeptidase N (CD13) in infection of human neural cells by human coronavirus 229E.

10. Coronavirus immunoreactivity in individuals with a recent onset of psychotic symptoms.