Literature DB >> 8985410

Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS.

Y Yoshikai1, H Kidokoro, K Kimura, Y Aoki, M Makino, K Hiromatsu.   

Abstract

Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.

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Year:  1997        PMID： 8985410      PMCID： PMC191111     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  20 in total

1.  Protective effect of cyclosporin A on immune abnormalities observed in the murine acquired immunodeficiency syndrome.

Authors:  A Cerny; R Merino; M Makino; F A Waldvogel; H C Morse; S Izui
Journal:  Eur J Immunol       Date:  1991-07       Impact factor: 5.532

2.  Stimulation of all T cells bearing V beta 1, V beta 3, V beta 11 and V beta 12 by staphylococcal enterotoxin A.

Authors:  H Takimoto; Y Yoshikai; K Kishihara; G Matsuzaki; H Kuga; T Otani; K Nomoto
Journal:  Eur J Immunol       Date:  1990-03       Impact factor: 5.532

Review 3.  Murine acquired immunodeficiency syndrome (MAIDS): an animal model to study the AIDS pathogenesis.

Authors:  P Jolicoeur
Journal:  FASEB J       Date:  1991-07       Impact factor: 5.191

4.  Expansion and clonal deletion of peripheral T cells induced by bacterial superantigen is independent of the interleukin-2 pathway.

Authors:  J A Gonzalo; I Moreno de Alborán; J E Alés-Martínez; C Martínez; G Kroemer
Journal:  Eur J Immunol       Date:  1992-04       Impact factor: 5.532

5.  Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.

Authors:  J Liu; J D Farmer; W S Lane; J Friedman; I Weissman; S L Schreiber
Journal:  Cell       Date:  1991-08-23       Impact factor: 41.582

6.  Retrovirus-induced murine acquired immunodeficiency syndrome: natural history of infection and differing susceptibility of inbred mouse strains.

Authors:  J W Hartley; T N Fredrickson; R A Yetter; M Makino; H C Morse
Journal:  J Virol       Date:  1989-03       Impact factor: 5.103

7.  A selective signaling defect in helper T cells induced by antigen-presenting cells from mice with murine acquired immunodeficiency syndrome.

Authors:  T Mizuochi; J Mizuguchi; T Uchida; K Ohnishi; M Nakanishi; Y Asano; T Kakiuchi; Y Fukushima; K Okuyama; H C Morse
Journal:  J Immunol       Date:  1990-01-01       Impact factor: 5.422

Review 8.  Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction.

Authors:  N H Sigal; F J Dumont
Journal:  Annu Rev Immunol       Date:  1992       Impact factor: 28.527

9.  Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis.

Authors:  M J Lenardo
Journal:  Nature       Date:  1991-10-31       Impact factor: 49.962

10.  Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS).

Authors:  D E Mosier; R A Yetter; H C Morse
Journal:  J Exp Med       Date:  1987-06-01       Impact factor: 14.307
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