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Literature DB >> 3035057

Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS).

Abstract

Athymic nu/nu mice were found to be resistant to the immunodeficiency disease and lethality induced in normal mice by the injection of the LP-BM5 mixture of murine retroviruses (LP-BM5 MuLV). Susceptibility to disease induction was reconstituted by injection of nu/nu mice with purified, mature T lymphocytes. The extent of viral replication of both the ecotropic and mink cell focus forming (MCF) components of LP-BM5 MuLV was equivalent in both nu/nu and normal animals. Retrovirally-induced immunodeficiency disease in mice (MAIDS) is thus dependent upon the presence of functional T lymphocytes, and high virus titers in athymic mice have little or no effect on the immune system.

Entities: Disease Species

Mesh：

Year: 1987 PMID： 3035057 PMCID： PMC2188367 DOI： 10.1084/jem.165.6.1737

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

17 in total

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51 in total

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Journal: Antivir Chem Chemother Date: 2014-12-16

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Journal: Virology Date: 2006-11-17 Impact factor: 3.616

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10. Reciprocal relationship of T regulatory cells and monocytic myeloid-derived suppressor cells in LP-BM5 murine retrovirus-induced immunodeficiency.

Authors: Megan A O'Connor; Jennifer L Vella; William R Green
Journal: J Gen Virol Date: 2015-08-06 Impact factor: 3.891