R O Howard1. 1. Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA.
Abstract
PURPOSE: To present data to support the hypothesis that human retinoblastoma tumors form by a multistep process. METHODS: Survey of the karyotype of 90 human retinoblastomas, with emphasis on changes in chromosomal regions known to contain oncogenes and tumor suppressor genes. CONCLUSION: The data support the hypothesis that retinoblastoma occurs after multiple and often varied steps, similar to other human malignancies.
PURPOSE: To present data to support the hypothesis that humanretinoblastoma tumors form by a multistep process. METHODS: Survey of the karyotype of 90 humanretinoblastomas, with emphasis on changes in chromosomal regions known to contain oncogenes and tumor suppressor genes. CONCLUSION: The data support the hypothesis that retinoblastoma occurs after multiple and often varied steps, similar to other humanmalignancies.