Literature DB >> 8980779

Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis.

H S OZ1, W T Hughes, J E Rehg.   

Abstract

The efficacy of the ionophore lasalocid against Pneumocystis carinii pneumonitis in corticosteroid-immunosuppressed Sprague-Dawley rats was investigated. Lasalocid was effective in the prevention of the pneumonitis in a dose-dependent manner. At dosages of 0, 5, 10, and 20 mg/kg/day, P. carinii infection rates were 92, 60, 20, and 0%, respectively, during dexamethasone immunosuppression. Also, lasalocid compared favorably with other drugs known to have anti-P. carinii activity, including trimethoprim-sulfamethoxazole, atovaquone, and dapsone-trimethoprim.

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Year:  1997        PMID： 8980779      PMCID： PMC163684     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Successful treatment with aerosolized pentamidine of Pneumocystis carinii pneumonia in rats.

Authors:  R J Debs; W Blumenfeld; E N Brunette; R M Straubinger; A B Montgomery; E Lin; N Agabian; D Papahadjopoulos
Journal:  Antimicrob Agents Chemother       Date:  1987-01       Impact factor: 5.191

Review 2.  A literature review on the toxicity of lasalocid, a polyether antibiotic.

Authors:  S J Galitzer; F W Oehme
Journal:  Vet Hum Toxicol       Date:  1984-08

3.  Activity of clindamycin with primaquine against Pneumocystis carinii in vitro and in vivo.

Authors:  S F Queener; M S Bartlett; J D Richardson; M M Durkin; M A Jay; J W Smith
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

4.  Lasalocid-catalyzed proton conductance in Streptococcus bovis as affected by extracellular potassium.

Authors:  W R Schwingel; D B Bates; S C Denham; D K Beede
Journal:  Appl Environ Microbiol       Date:  1989-01       Impact factor: 4.792

5.  Biosynthesis of lasalocid. III. Isolation and structure determination of four homologs of lasalocid A.

Authors:  J W Westley; W Benz; J Donahue; R H Evans; C G Scott; A Stempel; J Berger
Journal:  J Antibiot (Tokyo)       Date:  1974-10       Impact factor: 2.649

6.  Toxic effects of lasalocid in horses.

Authors:  L J Hanson; H G Eisenbeis; S V Givens
Journal:  Am J Vet Res       Date:  1981-03       Impact factor: 1.156

7.  Studies on the stage of action of ionophorous antibiotics against Eimeria.

Authors:  P L Long; T K Jeffers
Journal:  J Parasitol       Date:  1982-06       Impact factor: 1.276

8.  Efficacy of diaminodiphenylsulfone and other drugs in murine Pneumocystis carinii pneumonitis.

Authors:  W T Hughes; B L Smith
Journal:  Antimicrob Agents Chemother       Date:  1984-10       Impact factor: 5.191

9.  Efficacy of trimethoprim and sulfamethoxazole in the prevention and treatment of Pneumocystis carinii pneumonitis.

Authors:  W T Hughes; P C McNabb; T D Makres; S Feldman
Journal:  Antimicrob Agents Chemother       Date:  1974-03       Impact factor: 5.191

10.  Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent.

Authors:  C J Allegra; J A Kovacs; J C Drake; J C Swan; B A Chabner; H Masur
Journal:  J Exp Med       Date:  1987-03-01       Impact factor: 14.307
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  3 in total

1.  Short-term exposure to membrane-active antibiotics inhibits Cryptosporidium parvum infection in cell culture.

Authors:  A Giacometti; O Cirioni; M S Del Prete; F Barchiesi; G Scalise
Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191

2.  Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites.

Authors:  Dion A Kevin Ii; Damaris Af Meujo; Mark T Hamann
Journal:  Expert Opin Drug Discov       Date:  2009-02       Impact factor: 6.098

3.  "Human babesiosis": an emerging transfusion dilemma.

Authors:  Helieh S Oz; Karin H Westlund
Journal:  Int J Hepatol       Date:  2012-03-28
  3 in total

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