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Literature DB >> 4365115

Efficacy of trimethoprim and sulfamethoxazole in the prevention and treatment of Pneumocystis carinii pneumonitis.

W T Hughes, P C McNabb, T D Makres, S Feldman.

Abstract

A combination of trimethoprim and sulfamethoxazole was effective in the prevention and treatment of Pneumocystis carinii pneumonitis in cortisonetreated rats. Although all of 15 untreated rats died with P. carinii pneumonitis, none of 15 given trimethoprim-sulfamethoxazole prophylactically acquired the infection. After P. carinii pneumonitis was established, 9 of 14 rats recovered after treatment with trimethoprim-sulfamethoxazole compared with only 2 of 14 treated with pentamidine isethionate. Rifampin and clindamycin, separately or in combination with pentamidine, were ineffective in the prevention and treatment of P. carinii infection.

Entities: Chemical Disease Species

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Year: 1974 PMID： 4365115 PMCID： PMC428962 DOI： 10.1128/AAC.5.3.289

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

17 in total

1. Therapy of natural falciparum malaria with combinations of antifolic drugs in non-immune subjects.

Authors: L Donno; V Sanguineti
Journal: Chemotherapy Date: 1970 Impact factor: 2.544

2. Immunosuppressive powers of the antibacterial agent trimethoprim.

Authors: M W Ghilchik; A S Morris; D S Reeves
Journal: Nature Date: 1970-07-25 Impact factor: 49.962

3. Pentamidine isethionate in the treatment of Pneumocystis carinii pneumonia.

Authors: K A Western; D R Perera; M G Schultz
Journal: Ann Intern Med Date: 1970-11 Impact factor: 25.391

4. Toxicology of sulphonamide-trimethoprim combinations.

Authors: V Udall
Journal: Postgrad Med J Date: 1969-11 Impact factor: 2.401

5. Latent Pneumocystis infection of rats, relapse, and chemotherapy.

Authors: J K Frenkel; J T Good; J A Shultz
Journal: Lab Invest Date: 1966-10 Impact factor: 5.662

6. The effect of rifampin on Toxoplasma gondii.

Authors: J S Remington; T Yagura; W S Robinson
Journal: Proc Soc Exp Biol Med Date: 1970-10

7. Pharmacokinetics of sulfamethoxazole plus trimethoprim in man and their distribution in the rat.

Authors: D E Schwartz; J Rieder
Journal: Chemotherapy Date: 1970 Impact factor: 2.544

8. Antiplasmodial activity of halogenated lincomycin analogues in Plasmodium berghei-infected mice.

Authors: C Lewis
Journal: Antimicrob Agents Chemother (Bethesda) Date: 1967

9. Prophylaxis of epidemic infantile pneumocystosis with a 20:1 sulfadoxine+pyrimethamine combination.

Authors: C Post; T Fakouhi; W Dutz; B Bandarizadeh; E E Kohout
Journal: Curr Ther Res Clin Exp Date: 1971-05

10. In vitro antibacterial activity of trimethoprim alone and combined with sulfonamides.

Authors: B Reisberg; J Herzog; L Weinstein
Journal: Antimicrob Agents Chemother (Bethesda) Date: 1966

70 in total

Review 1. Pneumocystis carinii, an opportunist in immunocompromised patients.

Authors: M S Bartlett; J W Smith
Journal: Clin Microbiol Rev Date: 1991-04 Impact factor: 26.132

2. First experience with pentamidine inhalation in human immunodeficiency virus-infected children.

Authors: W Kreuz; T Güngör; M Funk; R Linde; S Ehrenforth; C Lotz; B Kornhuber
Journal: Eur J Pediatr Date: 1991-07 Impact factor: 3.183

3. Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase.

Authors: Vivian Cody; Jim Pace; Jennifer Piraino; Sherry F Queener
Journal: J Struct Biol Date: 2011-06-13 Impact factor: 2.867

Efficacy of trimethoprim and sulfamethoxazole in the prevention and treatment of Pneumocystis carinii pneumonitis.

1. Therapy of natural falciparum malaria with combinations of antifolic drugs in non-immune subjects.

2. Immunosuppressive powers of the antibacterial agent trimethoprim.

3. Pentamidine isethionate in the treatment of Pneumocystis carinii pneumonia.

4. Toxicology of sulphonamide-trimethoprim combinations.

5. Latent Pneumocystis infection of rats, relapse, and chemotherapy.

6. The effect of rifampin on Toxoplasma gondii.

7. Pharmacokinetics of sulfamethoxazole plus trimethoprim in man and their distribution in the rat.

8. Antiplasmodial activity of halogenated lincomycin analogues in Plasmodium berghei-infected mice.

9. Prophylaxis of epidemic infantile pneumocystosis with a 20:1 sulfadoxine+pyrimethamine combination.

10. In vitro antibacterial activity of trimethoprim alone and combined with sulfonamides.

Review 1. Pneumocystis carinii, an opportunist in immunocompromised patients.

2. First experience with pentamidine inhalation in human immunodeficiency virus-infected children.

3. Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase.

4. Treatment of Pneumocystis carinii pneumonia with 1,3-beta-glucan synthesis inhibitors.

5. Trimethoprim-sulfamethoxazole desensitization in AIDS.

6. Activity of clindamycin with primaquine against Pneumocystis carinii in vitro and in vivo.

7. Pneumocystis pneumonia. Animal model: pneumocystis cartinii pneumonia in the immunosuppressed rat.

8. Experimental Pneumocystis carinii pneumonia in different strains of cortisonized mice.

9. Limited effect of trimethoprim-sulfamethoxazole prophylaxis on Pneumocystis carinii.

10. Improved rat model of Pneumocystis carinii pneumonia: induced laboratory infections in Pneumocystis-free animals.