Literature DB >> 8978833

Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets.

H T Lee1, D R Sliskovic, J A Picard, B D Roth, W Wierenga, J L Hicks, R F Bousley, K L Hamelehle, R Homan, C Speyer, R L Stanfield, B R Krause.   

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Year:  1996        PMID： 8978833     DOI： 10.1021/jm960674d

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  11 in total

1.  Effect of SMP-500, a novel ACAT inhibitor, on hepatic cholesterol disposition in rats.

Authors:  Katsuhisa Ioriya; Takeshi Nishimura; Naohito Ohashi
Journal:  Lipids       Date:  2002-04       Impact factor: 1.880

2.  Avasimibe encapsulated in human serum albumin blocks cholesterol esterification for selective cancer treatment.

Authors:  Steve Seung-Young Lee; Junjie Li; Jien Nee Tai; Timothy L Ratliff; Kinam Park; Ji-Xin Cheng
Journal:  ACS Nano       Date:  2015-02-16       Impact factor: 15.881

3.  Clonoamide, a new inhibitor of sterol O-acyltransferase, produced by Clonostachys sp. BF-0131.

Authors:  Keisuke Kobayashi; Nobuaki Tsukasaki; Ryuji Uchida; Yuichi Yamaguchi; Hiroshi Tomoda
Journal:  J Antibiot (Tokyo)       Date:  2015-04-22       Impact factor: 2.649

4.  Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood.

Authors:  Jun Zhang; Kathryn L Kelley; Stephanie M Marshall; Matthew A Davis; Martha D Wilson; Janet K Sawyer; Robert V Farese; J Mark Brown; Lawrence L Rudel
Journal:  J Lipid Res       Date:  2012-03-29       Impact factor: 5.922

5.  Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.

Authors:  M Accad; S J Smith; D L Newland; D A Sanan; L E King; M F Linton; S Fazio; R V Farese
Journal:  J Clin Invest       Date:  2000-03       Impact factor: 14.808

6.  Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport syndrome.

Authors:  Xiaochen Liu; Gloria Michelle Ducasa; Shamroop Kumar Mallela; Jin-Ju Kim; Judith Molina; Alla Mitrofanova; Sydney Symone Wilbon; Mengyuan Ge; Antonio Fontanella; Christopher Pedigo; Javier Varona Santos; Robert G Nelson; Yelena Drexler; Gabriel Contreras; Hassan Al-Ali; Sandra Merscher; Alessia Fornoni
Journal:  Kidney Int       Date:  2020-07-30       Impact factor: 10.612

7.  In vitro exploration of ACAT contributions to lipid droplet formation during adipogenesis.

Authors:  Yuyan Zhu; Chih-Yu Chen; Junjie Li; Ji-Xin Cheng; Miran Jang; Kee-Hong Kim
Journal:  J Lipid Res       Date:  2018-03-16       Impact factor: 5.922

8.  Lipid-lowering effects of WAY-121,898, an inhibitor of pancreatic cholesteryl ester hydrolase.

Authors:  B R Krause; D R Sliskovic; M Anderson; R Homan
Journal:  Lipids       Date:  1998-05       Impact factor: 1.880

9.  Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis.

Authors:  Feng Geng; Xiang Cheng; Xiaoning Wu; Ji Young Yoo; Chunming Cheng; Jeffrey Yunhua Guo; Xiaokui Mo; Peng Ru; Brian Hurwitz; Sung-Hak Kim; Jose Otero; Vinay Puduvalli; Etienne Lefai; Jianjie Ma; Ichiro Nakano; Craig Horbinski; Balveen Kaur; Arnab Chakravarti; Deliang Guo
Journal:  Clin Cancer Res       Date:  2016-06-08       Impact factor: 12.531

Review 10.  Cholesterol absorption inhibitors for the treatment of hypercholesterolaemia.

Authors:  Thomas Sudhop; Klaus von Bergmann
Journal:  Drugs       Date:  2002       Impact factor: 9.546
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