Literature DB >> 25899123

Clonoamide, a new inhibitor of sterol O-acyltransferase, produced by Clonostachys sp. BF-0131.

Keisuke Kobayashi1, Nobuaki Tsukasaki2, Ryuji Uchida1,2, Yuichi Yamaguchi1,3, Hiroshi Tomoda1,2.   

Abstract

A new compound designated as clonoamide was isolated from a culture broth of the fungus Clonostachys sp. BF-0131 by solvent extraction, Diaion HP20 column chromatography, octadecylsilyl column chromatography and preparative HPLC as an inhibitor of sterol O-acyltransferase (SOAT). The structure of clonoamide was elucidated as 2-oxo-9E,11E-tridecandienyl acetamide by various spectral analyses including NMR. The compound inhibited SOAT1 and SOAT2 isozymes with IC50 values of 39 and 110 μm, respectively, in a cell-based assay using SOAT1- and SOAT2-expressing Chinese hamster ovary cells.

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Year:  2015        PMID： 25899123     DOI： 10.1038/ja.2015.37

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  24 in total

1.  Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets.

Authors:  H T Lee; D R Sliskovic; J A Picard; B D Roth; W Wierenga; J L Hicks; R F Bousley; K L Hamelehle; R Homan; C Speyer; R L Stanfield; B R Krause
Journal:  J Med Chem       Date:  1996-12-20       Impact factor: 7.446

2.  Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice.

Authors:  K K Buhman; M Accad; S Novak; R S Choi; J S Wong; R L Hamilton; S Turley; R V Farese
Journal:  Nat Med       Date:  2000-12       Impact factor: 53.440

3.  A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels.

Authors:  Mami Ikenoya; Yasunobu Yoshinaka; Hideyuki Kobayashi; Katsumi Kawamine; Kimiyuki Shibuya; Fumiyasu Sato; Kimio Sawanobori; Takuya Watanabe; Akira Miyazaki
Journal:  Atherosclerosis       Date:  2006-07-03       Impact factor: 5.162

4.  Effects of HL-004, a novel ACAT inhibitor, on cholesterol accumulation and removal in cultured smooth muscle cells from stroke-prone spontaneously hypertensive rats (SHRSP).

Authors:  S Murakami; H Araki; S Otomo; Y Nara; Y Yamori
Journal:  Life Sci       Date:  1995       Impact factor: 5.037

5.  Dinapinones, novel inhibitors of triacylglycerol synthesis in mammalian cells, produced by Penicillium pinophilum FKI-3864.

Authors:  Satoshi Ohte; Daisuke Matsuda; Ryuji Uchida; Kenichi Nonaka; Rokuro Masuma; Satoshi Omura; Hiroshi Tomoda
Journal:  J Antibiot (Tokyo)       Date:  2011-05-11       Impact factor: 2.649

Review 6.  Isoform-specific inhibitors of ACATs: recent advances and promising developments.

Authors:  Taichi Ohshiro; Hiroshi Tomoda
Journal:  Future Med Chem       Date:  2011-12       Impact factor: 3.808

7.  Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice.

Authors:  Emily L Willner; Bryan Tow; Kimberly K Buhman; Martha Wilson; David A Sanan; Lawrence L Rudel; Robert V Farese
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-21       Impact factor: 11.205

8.  Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells.

Authors:  C C Chang; H Y Huh; K M Cadigan; T Y Chang
Journal:  J Biol Chem       Date:  1993-10-05       Impact factor: 5.157

9.  Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages.

Authors:  Ichiji Namatame; Hiroshi Tomoda; Shun Ishibashi; Satoshi Omura
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-12       Impact factor: 11.205

10.  Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates.

Authors:  R A Anderson; C Joyce; M Davis; J W Reagan; M Clark; G S Shelness; L L Rudel
Journal:  J Biol Chem       Date:  1998-10-09       Impact factor: 5.157
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  2 in total

1.  Pseudopyronine B, an inhibitor of sterol O-acyltransferase, produced by Pseudomonas sp. BYK11209.

Authors:  Aika Suzuki; Takashi Fukuda; Keisuke Kobayashi; Taichi Ohshiro; Hiroshi Tomoda
Journal:  J Antibiot (Tokyo)       Date:  2016-05-11       Impact factor: 2.649

2.  A Mixture of Atropisomers Enhances Neutral Lipid Degradation in Mammalian Cells with Autophagy Induction.

Authors:  Keisuke Kobayashi; Satoshi Ohte; Taichi Ohshiro; Narihiro Ugaki; Hiroshi Tomoda
Journal:  Sci Rep       Date:  2018-08-14       Impact factor: 4.379
  2 in total

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