Literature DB >> 897669

A method for detecting 8-methoxypsoralen in the ocular lens.

S Lerman, R F Borkman.   

Abstract

The use of 8-methoxypsoralen for treating psoriasis could prove hazardous if this photosensitizing agent enters the ocular lens. Phosphorescence spectra of intact rat lenses reveal concentrations of 8-methoxypsoralen on the order 10(-5)M after intraperitoneal injection of 8-methoxypsoralen. There is evidence that this drug can function as a photosensitizing agent, enhancing ultraviolet-induced changes within the lens.

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Year:  1977        PMID: 897669     DOI: 10.1126/science.897669

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  7 in total

Review 1.  Determination of 8-methoxypsoralen in serum, aqueous, and lens: relation to long-wave ultraviolet phototoxicity in experimental and clinical photochemotherapy.

Authors:  W B Glew
Journal:  Trans Am Ophthalmol Soc       Date:  1979

2.  8-Methoxypsoralen-gas chromatographic determination and serum kinetics.

Authors:  J Gazith; W Schalla; H Schaefer
Journal:  Arch Dermatol Res       Date:  1978-11-10       Impact factor: 3.017

Review 3.  Psoriasis. A review of recent advances in treatment.

Authors:  E M Farber; L Nall
Journal:  Drugs       Date:  1984-10       Impact factor: 9.546

4.  Ocular kinetics of 8-methoxypsoralen. An experimental study with pigmented and albino rabbits without UVA-stimulation.

Authors:  L Salminen; G Wilén
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1981

5.  8-methoxypsoralen and long ultraviolet effects on the rat lens: experiments with high dosage.

Authors:  H R Koch; R Beitzen; F Kremer; G Chioralia; H Baurmann; J Megaw; K Gardner; S Lerman
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1982       Impact factor: 3.117

6.  A retrospective study of ocular findings in patients treated with PUVA.

Authors:  R J Boukes; A T van Balen; D P Bruynzeel
Journal:  Doc Ophthalmol       Date:  1985-01-31       Impact factor: 2.379

Review 7.  Photochemotherapy in psoriasis: a review.

Authors:  D V Briffa; A P Warin
Journal:  J R Soc Med       Date:  1979-06       Impact factor: 18.000

  7 in total

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