Literature DB >> 8973538

Apoptosis and CD8-down-regulation in the thymus of chickens infected with Marek's disease virus.

T Morimura1, K Ohashi, Y Kon, M Hattori, C Sugimoto, M Onuma.   

Abstract

Marek's disease virus (MDV)-infected chickens show thymic atrophy during the acute phase of infection. We examined whether the thymic atrophy by MDV-infection was mediated by apoptosis. Apoptosis-specific DNA ladderings were clearly observed in thymocytes one week after MDV-infection. Histological and flow cytometry studies revealed that immature CD4+ CD8+ thymocytes underwent apototic cell death. In addition, the expression level of CD8 molecules on both CD4(-)CD8+ and CD4+ CD8+ thymocyte populations was down-regulated in the infected chickens. These thymic changes might be involved in the pathogenesis of Marek's disease.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8973538     DOI： 10.1007/bf01718230

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  13 in total

Review 1.  Marek's disease: a model for protection against herpesvirus-induced tumours.

Authors:  K A Schat
Journal:  Cancer Surv       Date:  1987

Review 2.  From AIDS to parasite infection: pathogen-mediated subversion of programmed cell death as a mechanism for immune dysregulation.

Authors:  J C Ameisen; J Estaquier; T Idziorek
Journal:  Immunol Rev       Date:  1994-12       Impact factor: 12.988

3.  Identification of the avian homologues of mammalian CD4 and CD8 antigens.

Authors:  M M Chan; C L Chen; L L Ager; M D Cooper
Journal:  J Immunol       Date:  1988-04-01       Impact factor: 5.422

4.  CD8 is needed for development of cytotoxic T cells but not helper T cells.

Authors:  W P Fung-Leung; M W Schilham; A Rahemtulla; T M Kündig; M Vollenweider; J Potter; W van Ewijk; T W Mak
Journal:  Cell       Date:  1991-05-03       Impact factor: 41.582

5.  A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes.

Authors:  I A York; C Roop; D W Andrews; S R Riddell; F L Graham; D C Johnson
Journal:  Cell       Date:  1994-05-20       Impact factor: 41.582

6.  Comparative pathogenesis studies with oncogenic and nononcogenic Marek's disease viruses and turkey herpesvirus.

Authors:  B W Calnek; J C Carlisle; J Fabricant; K K Murthy; K A Schat
Journal:  Am J Vet Res       Date:  1979-04       Impact factor: 1.156

7.  Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse.

Authors:  H Kaneshima; L Su; M L Bonyhadi; R I Connor; D D Ho; J M McCune
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

8.  Immunomodulation of peripheral T cells in chickens infected with Marek's disease virus: involvement in immunosuppression.

Authors:  T Morimura; M Hattori; K Ohashi; C Sugimoto; M Onuma
Journal:  J Gen Virol       Date:  1995-12       Impact factor: 3.891

9.  Human T lymphocyte virus 1 from a leukemogenic cell line mediates in vivo and in vitro lymphocyte apoptosis.

Authors:  M Leno; R M Simpson; F S Bowers; T J Kindt
Journal:  J Exp Med       Date:  1995-04-01       Impact factor: 14.307

10.  Immune recognition of HLA molecules downmodulates CD8 expression on cytotoxic T lymphocytes.

Authors:  P A Robbins; A J McMichael
Journal:  J Exp Med       Date:  1991-01-01       Impact factor: 14.307
View more
  11 in total

1.  The CD8α gene in duck (Anatidae): cloning, characterization, and expression during viral infection.

Authors:  Qi Xu; Yang Chen; Wen Ming Zhao; Zheng Yang Huang; Xiu Jun Duan; Yi Yu Tong; Yang Zhang; Xiu Li; Guo Bin Chang; Guo Hong Chen
Journal:  Mol Biol Rep       Date:  2014-10-21       Impact factor: 2.316

2.  Marek's disease virus may interfere with T cell immunity by TLR3 signals.

Authors:  Xuming Hu; Wencai Xu; Aijian Qin; Genghua Wu; Kun Qian; Hongxia Shao; Jianqiang Ye
Journal:  Vet Res Commun       Date:  2014-03-02       Impact factor: 2.459

3.  Systems analysis of immune responses in Marek's disease virus-infected chickens identifies a gene involved in susceptibility and highlights a possible novel pathogenicity mechanism.

Authors:  Jacqueline Smith; Jean-Remy Sadeyen; Ian R Paton; Paul M Hocking; Nigel Salmon; Mark Fife; Venugopal Nair; David W Burt; Pete Kaiser
Journal:  J Virol       Date:  2011-08-24       Impact factor: 5.103

4.  Molecular characterization of immunoinhibitory factors PD-1/PD-L1 in chickens infected with Marek's disease virus.

Authors:  Ayumi Matsuyama-Kato; Shiro Murata; Masayoshi Isezaki; Rika Kano; Sara Takasaki; Osamu Ichii; Satoru Konnai; Kazuhiko Ohashi
Journal:  Virol J       Date:  2012-05-21       Impact factor: 4.099

5.  DNA Methylation Fluctuation Induced by Virus Infection Differs between MD-resistant and -susceptible Chickens.

Authors:  Juan Luo; Ying Yu; Shuang Chang; Fei Tian; Huanmin Zhang; Jiuzhou Song
Journal:  Front Genet       Date:  2012-02-17       Impact factor: 4.599

6.  Marek's disease virus infection induces widespread differential chromatin marks in inbred chicken lines.

Authors:  Apratim Mitra; Juan Luo; Huanming Zhang; Kairong Cui; Keji Zhao; Jiuzhou Song
Journal:  BMC Genomics       Date:  2012-10-16       Impact factor: 3.969

7.  Analysis of protein expression profiles in the thymus of chickens infected with Marek's disease virus.

Authors:  Xuming Hu; Aijian Qin; Kun Qian; Hongxia Shao; Chuan Yu; Wencai Xu; Ji Miao
Journal:  Virol J       Date:  2012-11-01       Impact factor: 4.099

8.  Atrophy of primary lymphoid organs induced by Marek's disease virus during early infection is associated with increased apoptosis, inhibition of cell proliferation and a severe B-lymphopenia.

Authors:  Camille Berthault; Thibaut Larcher; Sonja Härtle; Jean-François Vautherot; Laetitia Trapp-Fragnet; Caroline Denesvre
Journal:  Vet Res       Date:  2018-03-27       Impact factor: 3.683

9.  Analyses of the spleen proteome of chickens infected with Marek's disease virus.

Authors:  Niroshan Thanthrige-Don; Mohamed F Abdul-Careem; L Allen Shack; Shane C Burgess; Shayan Sharif
Journal:  Virology       Date:  2009-06-21       Impact factor: 3.616

Review 10.  Virus-induced immunosuppression in turkeys (Meleagris gallopavo): A review.

Authors:  Khaled Kaboudi
Journal:  Open Vet J       Date:  2019-12-25
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.