| Literature DB >> 24585377 |
Xuming Hu1, Wencai Xu, Aijian Qin, Genghua Wu, Kun Qian, Hongxia Shao, Jianqiang Ye.
Abstract
Marek's disease virus (MDV) is a highly oncogenic alpha-herpesvirus that causes T cell immune suppression and malignant lymphomas in chickens. Toll-like receptor (TLR) plays a dominant role in antiviral T cell immunity. However, it is unclear whether MDV induced T cell immunity is associated with TLR-mediated immunity. In this study, the expression of 28 host genes that are involved in TLR-mediated immunity and MHC-medicated T cell immunity was evaluated in chicken thymus at 7, 14, 21 and 28 days post-infection (dpi). Our results demonstrated that 24 host immune-related genes were upregulated during MDV infection at 7 dpi; however, the expression of most of these genes decreased at 21 and 28 dpi. Notably, a positive correlation was found between the down-regulation of CD4, CD8 and TLR3 signals but not the MyD88-dependent TLR pathway. The present study expanded our knowledge of host immune responses against MDV infection and our results might provide a clue that MDV may interfere with T cell immune response through TLR3 signals.Entities:
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Year: 2014 PMID： 24585377 DOI： 10.1007/s11259-014-9598-x
Source DB: PubMed Journal: Vet Res Commun ISSN： 0165-7380 Impact factor: 2.459