Literature DB >> 8970987

Influenza virus neuraminidase activates latent transforming growth factor beta.

S Schultz-Cherry1, V S Hinshaw.   

Abstract

Transforming growth factor beta (TGF-beta) is a family of proteins secreted by virtually all cells in a biologically inactive form. TGF-beta levels increase during many pathophysiological situations, including viral infection. The mechanism for increased TGF-beta activity during viral infection is not understood. We observed an increase in active TGF-beta levels within 1 day in mice infected with influenza virus. Further studies showed that the neuraminidase glycoprotein of influenza A and B viruses directly activates latent TGF-beta in vitro. There are sufficient levels of TGF-beta activated by virus to induce apoptosis in cells. In addition, influenza virus-induced apoptosis is partially inhibited by TGF-beta-specific antibodies. These novel findings suggest a potential role for activation of TGF-beta during the host response to influenza virus infection, specifically apoptosis. This is the first report showing direct activation of latent TGF-beta by a viral protein.

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Year:  1996        PMID： 8970987      PMCID： PMC190955     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  25 in total

1.  Neutralizing epitopes of the H5 hemagglutinin from a virulent avian influenza virus and their relationship to pathogenicity.

Authors:  M Philpott; B C Easterday; V S Hinshaw
Journal:  J Virol       Date:  1989-08       Impact factor: 5.103

Review 2.  TGF-beta: structure, function, and formation.

Authors:  D B Rifkin; S Kojima; M Abe; J G Harpel
Journal:  Thromb Haemost       Date:  1993-07-01       Impact factor: 5.249

Review 3.  Transforming growth factor-beta.

Authors:  J Massagué; S Cheifetz; M Laiho; D A Ralph; F M Weis; A Zentella
Journal:  Cancer Surv       Date:  1992

4.  Role for carbohydrate structures in TGF-beta 1 latency.

Authors:  K Miyazono; C H Heldin
Journal:  Nature       Date:  1989-03-09       Impact factor: 49.962

5.  Protection against lethal influenza with neuraminidase.

Authors:  R G Webster; P A Reay; W G Laver
Journal:  Virology       Date:  1988-05       Impact factor: 3.616

Review 6.  Transforming growth factor beta (TGF-beta) in inflammation: a cause and a cure.

Authors:  S M Wahl
Journal:  J Clin Immunol       Date:  1992-03       Impact factor: 8.317

7.  Virulent avian influenza A viruses: their effect on avian lymphocytes and macrophages in vivo and in vitro.

Authors:  H Van Campen; B C Easterday; V S Hinshaw
Journal:  J Gen Virol       Date:  1989-11       Impact factor: 3.891

8.  Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism.

Authors:  S Schultz-Cherry; J E Murphy-Ullrich
Journal:  J Cell Biol       Date:  1993-08       Impact factor: 10.539

9.  Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia.

Authors:  S J Kim; J H Kehrl; J Burton; C L Tendler; K T Jeang; D Danielpour; C Thevenin; K Y Kim; M B Sporn; A B Roberts
Journal:  J Exp Med       Date:  1990-07-01       Impact factor: 14.307

10.  Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia.

Authors:  S R Carding; W Allan; A McMickle; P C Doherty
Journal:  J Exp Med       Date:  1993-02-01       Impact factor: 14.307
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  104 in total

1.  Dose-dependent changes in influenza virus-infected dendritic cells result in increased allogeneic T-cell proliferation at low, but not high, doses of virus.

Authors:  SangKon Oh; J Michael McCaffery; Maryna C Eichelberger
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

Review 2.  Molecular pathways in virus-induced cytokine production.

Authors:  T H Mogensen; S R Paludan
Journal:  Microbiol Mol Biol Rev       Date:  2001-03       Impact factor: 11.056

Review 3.  Cytopathogenesis and inhibition of host gene expression by RNA viruses.

Authors:  D S Lyles
Journal:  Microbiol Mol Biol Rev       Date:  2000-12       Impact factor: 11.056

4.  Transforming growth factor beta is a major regulator of human neonatal immune responses following respiratory syncytial virus infection.

Authors:  Natalie J Thornburg; Bryan Shepherd; James E Crowe
Journal:  J Virol       Date:  2010-10-06       Impact factor: 5.103

5.  Polarization of allogeneic T-cell responses by influenza virus-infected dendritic cells.

Authors:  Sangkon Oh; Maryna C Eichelberger
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

Review 6.  Postinfluenza bacterial pneumonia: host defenses gone awry.

Authors:  Megan N Ballinger; Theodore J Standiford
Journal:  J Interferon Cytokine Res       Date:  2010-09       Impact factor: 2.607

Review 7.  The threat of avian influenza a (H5N1): part II: Clues to pathogenicity and pathology.

Authors:  Jindrich Cinatl; Martin Michaelis; Hans W Doerr
Journal:  Med Microbiol Immunol       Date:  2007-04-04       Impact factor: 3.402

8.  Influenza virus neuraminidase contributes to secondary bacterial pneumonia.

Authors:  Ville T Peltola; K Gopal Murti; Jonathan A McCullers
Journal:  J Infect Dis       Date:  2005-06-08       Impact factor: 5.226

Review 9.  Transforming growth factor beta (TGF-beta) and inflammation in cancer.

Authors:  Brian Bierie; Harold L Moses
Journal:  Cytokine Growth Factor Rev       Date:  2009-12-16       Impact factor: 7.638

10.  Astrovirus induces diarrhea in the absence of inflammation and cell death.

Authors:  Matthew D Koci; Lindsey A Moser; Laura A Kelley; Diane Larsen; Corrie C Brown; Stacey Schultz-Cherry
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103
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