Literature DB >> 2358774

Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia.

S J Kim1, J H Kehrl, J Burton, C L Tendler, K T Jeang, D Danielpour, C Thevenin, K Y Kim, M B Sporn, A B Roberts.   

Abstract

We examined the effect of the human T lymphotropic virus type 1 (HTLV-I) Tax gene product on the human transforming growth factor beta 1 (TGF-beta 1) promoter. Transfection of deleted constructs of the TGF-beta 1 promoter revealed regions homologous with AP-1 binding sites that were required for Tax-induced transactivation of the TGF-beta 1 promoter. In addition, we examined the expression and secretion of TGF-beta in fresh leukemic cells isolated from patients with adult T cell leukemia (ATL) and in HTLV-1-infected T cell lines. We report that fresh leukemic cells from ATL patients constitutively produce high levels of TGF-beta 1 mRNA and secrete TGF-beta 1 but not TGF-beta 2 into the culture medium. In addition, long-term ATL cell lines expressed significant amounts of TGF-beta 1 mRNA as well as detectable levels of TGF-beta 1 protein. These results suggest a role for Tax in the upregulation of TGF-beta 1 in HTLV-I-infected cells.

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Year:  1990        PMID： 2358774      PMCID： PMC2188182          DOI： 10.1084/jem.172.1.121

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  61 in total

1.  Genomic sequencing.

Authors:  G M Church; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

2.  HTLV-I-associated lymphoma involving the entire alimentary tract and presenting with an acquired immune deficiency.

Authors:  M S Cappell; J Chow
Journal:  Am J Med       Date:  1987-03-23       Impact factor: 4.965

3.  Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat.

Authors:  J Brady; K T Jeang; J Duvall; G Khoury
Journal:  J Virol       Date:  1987-07       Impact factor: 5.103

4.  Functional and phenotypic comparison of human T cell leukemia/lymphoma virus positive adult T cell leukemia with human T cell leukemia/lymphoma virus negative Sézary leukemia, and their distinction using anti-Tac. Monoclonal antibody identifying the human receptor for T cell growth factor.

Authors:  T A Waldmann; W C Greene; P S Sarin; C Saxinger; D W Blayney; W A Blattner; C K Goldman; K Bongiovanni; S Sharrow; J M Depper
Journal:  J Clin Invest       Date:  1984-06       Impact factor: 14.808

Review 5.  NIH conference. T-cell lymphoproliferative syndrome associated with human T-cell leukemia/lymphoma virus.

Authors:  S Broder; P A Bunn; E S Jaffe; W Blattner; R C Gallo; F Wong-Staal; T A Waldmann; V T DeVita
Journal:  Ann Intern Med       Date:  1984-04       Impact factor: 25.391

Review 6.  Human T-cell leukemia virus: its discovery and role in leukemogenesis and immunosuppression.

Authors:  G M Shaw; S Broder; M Essex; R C Gallo
Journal:  Adv Intern Med       Date:  1984

7.  Production of interleukin 1 by adult T cell leukemia (ATL) cell lines.

Authors:  U Yamashita; F Shirakawa; H Nakamura
Journal:  J Immunol       Date:  1987-05-15       Impact factor: 5.422

8.  Human T-cell leukemia virus (HTLV-I) transcripts in fresh and cultured cells of patients with adult T-cell leukemia.

Authors:  G Franchini; F Wong-Staal; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1984-10       Impact factor: 11.205

9.  Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors.

Authors:  M A Anzano; A B Roberts; J M Smith; M B Sporn; J E De Larco
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

10.  Complementary deoxyribonucleic acid cloning of bovine transforming growth factor-beta 1.

Authors:  E Van Obberghen-Schilling; P Kondaiah; R L Ludwig; M B Sporn; C C Baker
Journal:  Mol Endocrinol       Date:  1987-10
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  66 in total

Review 1.  Molecular pathways in virus-induced cytokine production.

Authors:  T H Mogensen; S R Paludan
Journal:  Microbiol Mol Biol Rev       Date:  2001-03       Impact factor: 11.056

2.  Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells.

Authors:  Roberta Castriconi; Claudia Cantoni; Mariella Della Chiesa; Massimo Vitale; Emanuela Marcenaro; Romana Conte; Roberto Biassoni; Cristina Bottino; Lorenzo Moretta; Alessandro Moretta
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-19       Impact factor: 11.205

3.  Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3.

Authors:  E Muñoz; G Courtois; P Veschambre; P Jalinot; A Israël
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

4.  Stimulation of alpha 1 (I) procollagen gene expression in NIH-3T3 cells by the human T cell leukemia virus type 1 (HTLV-1) Tax gene.

Authors:  E Muñoz; D Suri; S Amini; K Khalili; S A Jiménez
Journal:  J Clin Invest       Date:  1995-11       Impact factor: 14.808

5.  Increased number of circulating HTLV-1 infected cells in peripheral blood mononuclear cells of HTLV-1 uveitis patients: a quantitative polymerase chain reaction study.

Authors:  A Ono; M Mochizuki; K Yamaguchi; N Miyata; T Watanabe
Journal:  Br J Ophthalmol       Date:  1995-03       Impact factor: 4.638

6.  Infection of human synovial cells by human T cell lymphotropic virus type I. Proliferation and granulocyte/macrophage colony-stimulating factor production by synovial cells.

Authors:  M Sakai; K Eguchi; K Terada; M Nakashima; I Yamashita; H Ida; Y Kawabe; T Aoyagi; H Takino; T Nakamura
Journal:  J Clin Invest       Date:  1993-10       Impact factor: 14.808

7.  Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells.

Authors:  M O Westendorp; M Li-Weber; R W Frank; P H Krammer
Journal:  J Virol       Date:  1994-07       Impact factor: 5.103

8.  In vivo leukocyte tropism of bovine leukemia virus in sheep and cattle.

Authors:  I Schwartz; A Bensaid; B Polack; B Perrin; M Berthelemy; D Levy
Journal:  J Virol       Date:  1994-07       Impact factor: 5.103

9.  Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture.

Authors:  R Grassmann; S Berchtold; I Radant; M Alt; B Fleckenstein; J G Sodroski; W A Haseltine; U Ramstedt
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103

10.  Expression of a protein involved in bone resorption, Dkk1, is activated by HTLV-1 bZIP factor through its activation domain.

Authors:  Nicholas Polakowski; Heather Gregory; Jean-Michel Mesnard; Isabelle Lemasson
Journal:  Retrovirology       Date:  2010-07-23       Impact factor: 4.602
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