| Literature DB >> 8970730 |
T Lemberger1, B Desvergne, W Wahli.
Abstract
Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors that belong to the steroid/thyroid/retinoic acid receptor superfamily. All their characterized target genes encode proteins that participate in lipid homeostasis. The recent finding that antidiabetic thiazolidinediones and adipogenic prostanoids are ligands of one of the PPARs reveals a novel signaling pathway that directly links these compounds to processes involved in glucose homeostasis and lipid metabolism including adipocyte differentiation. A detailed understanding of this pathway could designate PPARs as targets for the development of novel efficient treatments for several metabolic disorders.Entities:
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Year: 1996 PMID： 8970730 DOI： 10.1146/annurev.cellbio.12.1.335
Source DB: PubMed Journal: Annu Rev Cell Dev Biol ISSN： 1081-0706 Impact factor: 13.827