| Literature DB >> 8946740 |
T Hu1, A S deFreitas, J M Curtis, Y Oshima, J A Walter, J L Wright.
Abstract
A new toxin, prorocentrolide B (1), has been isolated following bioassay-guided fractionation of a BuOH extract of the tropical dinoflagellate, Prorocentrum maculosum Faust. This compound produces a rapid toxic response in the mouse bioassay, a type of activity not accounted for by other diarrhetic shellfish poisoning toxins produced by P. maculosum. The structure 1 was established by NMR and MS and is similar to prorocentrolide (2), a toxin from a strain of Prorocentrum lima. NMR data and the modeling program ConGen have been used to establish the relative stereochemistry of some individual ether ring systems and the hexahydroisoquinoline ring.Entities:
Mesh：
Substances：
Year: 1996 PMID： 8946740 DOI： 10.1021/np960439y
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050