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Literature DB >> 8943351

Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex.

C M Horvath¹, G R Stark, I M Kerr, J E Darnell.

Abstract

The first STAT-containing transcription factor to be studied, the alpha-interferon-induced ISGF3, is composed of a Stat1:2 heterodimer and a weak DNA-binding protein, p48, that is a member of a growing family of proteins similar to the so-called interferon regulatory factor (IRF-1). The p48 and Stat1:2 heterodimer do not associate stably in the absence of DNA, but we show that amino acids approximately 150 to 250 of Stat1 and a COOH-terminal portion of p48 exhibit physical interaction, implying contact that stabilizes ISGF3. Moreover, amino acid exchanges within the Stat1 contact region diminish or abolish the functional activity of Stat1. This protein interaction domain may be important in other STAT proteins to recruit partners to multiprotein transcription factors.

Entities: Gene Species

Mesh：

Substances：

Year: 1996 PMID： 8943351 PMCID： PMC231699 DOI： 10.1128/MCB.16.12.6957

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

42 in total

1. Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

Authors: C Schindler; X Y Fu; T Improta; R Aebersold; J E Darnell
Journal: Proc Natl Acad Sci U S A Date: 1992-08-15 Impact factor: 11.205

2. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor.

Authors: C Schindler; K Shuai; V R Prezioso; J E Darnell
Journal: Science Date: 1992-08-07 Impact factor: 47.728

3. Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes.

Authors: D S Kessler; D E Levy; J E Darnell
Journal: Proc Natl Acad Sci U S A Date: 1988-11 Impact factor: 11.205

4. Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

Authors: N Reich; B Evans; D Levy; D Fahey; E Knight; J E Darnell
Journal: Proc Natl Acad Sci U S A Date: 1987-09 Impact factor: 11.205

5. Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

Authors: D S Kessler; S A Veals; X Y Fu; D E Levy
Journal: Genes Dev Date: 1990-10 Impact factor: 11.361

6. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes.

Authors: H Harada; T Fujita; M Miyamoto; Y Kimura; M Maruyama; A Furia; T Miyata; T Taniguchi
Journal: Cell Date: 1989-08-25 Impact factor: 41.582

7. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.

Authors: S A Veals; C Schindler; D Leonard; X Y Fu; R Aebersold; J E Darnell; D E Levy
Journal: Mol Cell Biol Date: 1992-08 Impact factor: 4.272

8. Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity.

Authors: S A Veals; T Santa Maria; D E Levy
Journal: Mol Cell Biol Date: 1993-01 Impact factor: 4.272

9. Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein.

Authors: K Shuai; C Schindler; V R Prezioso; J E Darnell
Journal: Science Date: 1992-12-11 Impact factor: 47.728

10. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

Authors: X Y Fu; C Schindler; T Improta; R Aebersold; J E Darnell
Journal: Proc Natl Acad Sci U S A Date: 1992-08-15 Impact factor: 11.205

64 in total

Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex.

1. Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

2. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor.

3. Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes.

4. Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

5. Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

6. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes.

7. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.

8. Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity.

9. Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein.

10. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

Review 1. Molecular mechanisms in T helper phenotype development.

2. Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein.

3. A Stat3-interacting protein (StIP1) regulates cytokine signal transduction.

4. A reinterpretation of the dimerization interface of the N-terminal domains of STATs.

5. Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity.

6. Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways.

Review 7. Transcriptional and chromatin regulation in interferon and innate antiviral gene expression.

8. Differential effects of mutations in NS4B on West Nile virus replication and inhibition of interferon signaling.

Review 9. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.

10. Nuclear transit of the intracellular domain of the interferon receptor subunit IFNaR2 requires Stat2 and Irf9.