OBJECTIVE: To investigate the type and distribution of psychiatric disorders in the child and adolescent members of extended pedigrees identified through bipolar probands. METHOD: The child and adolescent offspring (24 male, 26 female, aged 6 to 17 years) and the adult parents (60) of 14 bipolar pedigrees ascertained for the National Institutes of Mental Health Genetics Initiative Study of Bipolar Affective Disorder were personally assessed using structured psychiatric interviews. A parent was also interviewed about each child or adolescent offspring. RESULTS: Twelve of the 50 interviewed offspring received a lifetime DSM-III-R diagnosis of an affective disorder. This included six cases of bipolar disorder, five cases of major depressive disorder, and one case of dysthymia. Eight of the offspring who received an affective disorder diagnosis also qualified for an anxiety disorder (four), a disruptive behavior disorder (two), or both (two). Offspring who had a parent with an affective disorder had a 5.1-fold higher risk for receiving an affective disorder diagnosis than did offspring with healthy parents. CONCLUSIONS: In a consecutive series of families identified through a proband with bipolar disorder, there were significant increases in the prevalence of affective disorder diagnoses in the child and adolescent offspring. The distribution of illness in offspring was compatible with the presence of important genetic factors which contribute to early-onset affective illness.
OBJECTIVE: To investigate the type and distribution of psychiatric disorders in the child and adolescent members of extended pedigrees identified through bipolar probands. METHOD: The child and adolescent offspring (24 male, 26 female, aged 6 to 17 years) and the adult parents (60) of 14 bipolar pedigrees ascertained for the National Institutes of Mental Health Genetics Initiative Study of Bipolar Affective Disorder were personally assessed using structured psychiatric interviews. A parent was also interviewed about each child or adolescent offspring. RESULTS: Twelve of the 50 interviewed offspring received a lifetime DSM-III-R diagnosis of an affective disorder. This included six cases of bipolar disorder, five cases of major depressive disorder, and one case of dysthymia. Eight of the offspring who received an affective disorder diagnosis also qualified for an anxiety disorder (four), a disruptive behavior disorder (two), or both (two). Offspring who had a parent with an affective disorder had a 5.1-fold higher risk for receiving an affective disorder diagnosis than did offspring with healthy parents. CONCLUSIONS: In a consecutive series of families identified through a proband with bipolar disorder, there were significant increases in the prevalence of affective disorder diagnoses in the child and adolescent offspring. The distribution of illness in offspring was compatible with the presence of important genetic factors which contribute to early-onset affective illness.
Authors: Tomas Hajek; Jeffrey Cullis; Tomas Novak; Miloslav Kopecek; Ryan Blagdon; Lukas Propper; Pavla Stopkova; Anne Duffy; Cyril Hoschl; Rudolf Uher; Tomas Paus; L Trevor Young; Martin Alda Journal: Biol Psychiatry Date: 2012-07-20 Impact factor: 13.382
Authors: Tomas Hajek; Katja Franke; Marian Kolenic; Jana Capkova; Martin Matejka; Lukas Propper; Rudolf Uher; Pavla Stopkova; Tomas Novak; Tomas Paus; Miloslav Kopecek; Filip Spaniel; Martin Alda Journal: Schizophr Bull Date: 2019-01-01 Impact factor: 9.306
Authors: John I Nurnberger; Melvin McInnis; Wendy Reich; Elizabeth Kastelic; Holly C Wilcox; Anne Glowinski; Philip Mitchell; Carrie Fisher; Mariano Erpe; Elliot S Gershon; Wade Berrettini; Gina Laite; Robert Schweitzer; Kelly Rhoadarmer; Vegas V Coleman; Xueya Cai; Faouzi Azzouz; Hai Liu; Masoud Kamali; Christine Brucksch; Patrick O Monahan Journal: Arch Gen Psychiatry Date: 2011-10