| Literature DB >> 8934648 |
E I Korpelainen1, J R Gamble, M A Vadas, A F Lopez.
Abstract
IL-3 is a haemopoietic growth factor which stimulates the production and functional activity of various blood cell types. Recent evidence suggests that the target cell population of IL-3 is not restricted to haemopoietic cells as previously thought, but vascular cells such as endothelial cells also express receptors for and respond to this cytokine. Interestingly, IL-3 was found to regulate endothelial responses related to inflammation, immunity and haemopoiesis. These findings, summarized in this review, offer new insight into the physiological function of IL-3 and may also be of clinical importance, as IL-3 is used in bone marrow reconstitution following cancer therapy.Entities:
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Year: 1996 PMID： 8934648 DOI： 10.1038/icb.1996.1
Source DB: PubMed Journal: Immunol Cell Biol ISSN： 0818-9641 Impact factor: 5.126