Literature DB >> 893380

gamma-Aminobutyric acid metabolism in subcellular particles of mouse brain and its relationship to convulsions.

M Abe, M Matsuda.   

Abstract

The in vivo effects of convulsant drugs (hydrazine and penicillamine) on the metabolism of gamma-aminobutyric acid (GABA) in subcellular fractions of mouse brain were studied. Both substances inhibited the activity of glutamic acid decarboxylase [EC 4.1.1.15] (GAD) in the synaptosomal fraction (nerve ending particles) and reduced the concentration of GABA in the same fraction at the onset of convulsions, though changes in the total GABA concentration in the brain did not correlate with the onset of convulsions. Therefore, it is suggested that the concomitant decrease of GAD activity and GABA concentration in the nerve endings, independently of the total GABA concentration, is probably an important factor in the onset of some kinds of convulsions.

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Year:  1977        PMID： 893380     DOI： 10.1093/oxfordjournals.jbchem.a131669

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  8 in total

Review 1.  Cellular compartments of GABA in brain and their relationship to anticonvulsant activity.

Authors:  M J Iadarola; K Gale
Journal:  Mol Cell Biochem       Date:  1981-09-25       Impact factor: 3.396

2.  The antistress role of the GABAergic system of the brain.

Authors:  B V Andreev; Z S Nikitina; I A Sytinskii
Journal:  Neurosci Behav Physiol       Date:  1983 Nov-Dec

3.  Effect of repeated convulsive seizures on brain GABA levels.

Authors:  L Ciesielski; S Simler; P Mandel
Journal:  Neurochem Res       Date:  1981-03       Impact factor: 3.996

4.  Influence of short-lasting bilateral clamping of carotid arteries (BCCA) on GABA turnover in rat brain structures.

Authors:  M Sieklucka; W Löscher; C Heim; K H Sontag
Journal:  Neurochem Res       Date:  1994-03       Impact factor: 3.996

5.  Alterations in synaptosomal neurotransmitter amino acids in "petit-mal" rats at a daytime and a nighttime.

Authors:  S Simler; L Ciesielski; S Gobaille; P Mandel
Journal:  Neurochem Res       Date:  1990-11       Impact factor: 3.996

6.  On the existence of two GABA pools associated with newly synthesized GABA and with newly taken up GABA in nerve terminals.

Authors:  M Abe; M Matsuda
Journal:  Neurochem Res       Date:  1983-05       Impact factor: 3.996

7.  Relationship between drug-induced changes in seizure thresholds and the GABA content of brain and brain nerve endings.

Authors:  W Löscher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-09       Impact factor: 3.000

8.  Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments.

Authors:  S R Pagliusi; C Gomes; J R Leite; G Trolin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-04       Impact factor: 3.000
  8 in total

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