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Literature DB >> 7279106

Effect of repeated convulsive seizures on brain GABA levels.

Abstract

Repeated audiogenic seizures (4 times a day for 14 days), in genetically selected sensitive mice, induce a significant decrease in GABA level in the following brain areas: nucleus caudatus, posterior colliculus, occipital and frontal cortex, cerebellum, substantia nigra, hippocampus, amygdala, and temporal cortex. No variations were observed in olfactory bulbs, pons medulla, hypothalamus, thalamus, or cochlear area.

Entities: Chemical Disease Species

Mesh：

Substances：
gamma-Aminobutyric Acid

Year: 1981 PMID： 7279106 DOI： 10.1007/BF00964042

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

24 in total

1. gamma-Aminobutyric acid metabolism in subcellular particles of mouse brain and its relationship to convulsions.

Authors: M Abe; M Matsuda
Journal: J Biochem Date: 1977-07 Impact factor: 3.387

2. Neurochemical and morphological changes during the development of cobalt-induced epilepsy in the rat.

Authors: P C Emson; M H Joseph
Journal: Brain Res Date: 1975-07-25 Impact factor: 3.252

3. Stability of synaptosomal GABA levels and their use in determining the in vivo effects of drugs: convulsant agents.

Authors: J D Wood; M P Russell; E Kurylo; J D Newstead
Journal: J Neurochem Date: 1979-07 Impact factor: 5.372

4. Effect of sodium n-dipropylacetate on audiogenic seizures and brain -aminobutyric acid level.

Authors: S Simler; L Ciesielski; M Maitre; H Randrianarisoa; P Mandel
Journal: Biochem Pharmacol Date: 1973-07-15 Impact factor: 5.858

5. Amino acids in the cobalt-induced epileptogenic and nonepileptogenic cat's cortex.

Authors: I Koyama
Journal: Can J Physiol Pharmacol Date: 1972-08 Impact factor: 2.273

6. Regional changes in cerebral GABA concentration and convulsions produced by D and by L-allylglycine.

Authors: R W Horton; A G Chapman; B S Meldrum
Journal: J Neurochem Date: 1978-06 Impact factor: 5.372

7. Amino acid content of epileptogenic human brain: focal versus surrounding regions.

Authors: N M Van Gelder; A L Sherwin; T Rasmussen
Journal: Brain Res Date: 1972-05-26 Impact factor: 3.252

8. The effect of the convulsant allylglycine (2-amino-4-pentenoic acid) on the activity of glutamic acid decarboxylase and the concentration of GABA in different regions of guinea pig brain.

Authors: S K Fisher; W E Davies
Journal: Biochem Pharmacol Date: 1976-08-15 Impact factor: 5.858