Literature DB >> 893224

Fortimicins A and B, new aminoglycoside antibiotics. I. Producing organism, fermentation and biological properties of fortimicins.

T Nara, M Yamamoto, I Kawamoto, K Takayama, R Okachi, S Takasawa, T Sato, S Sato.   

Abstract

A culture of Micromonospora species MK-70 was found to produce two new antibiotics, fortimicins A and B. Antibacterial and paper chromatographic data on an eluate from IRC-50 treatment of fermentation beers indicated that fortimicins A and B are new antibiotics with broad-spectrum, basic and water-soluble properties. Fortimicin A exhibited potent, unique, broad-spectrum antibacterial activity against Gram-positive and negative bacteria both in vitro and in vivo, while fortimicin B was only weakly active.

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Year:  1977        PMID： 893224     DOI： 10.7164/antibiotics.30.533

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  17 in total

1.  Palladium-Catalyzed Dearomative syn-1,4-Diamination.

Authors:  William C Wertjes; Mikiko Okumura; David Sarlah
Journal:  J Am Chem Soc       Date:  2018-12-21       Impact factor: 15.419

Review 2.  Aminoglycoside research 1975-1985: prospects for development of improved agents.

Authors:  K E Price
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191

3.  Astromicin-induced membrane damage in Serratia marcescens.

Authors:  A Umeda; K Murata; K Amako
Journal:  Antimicrob Agents Chemother       Date:  1986-09       Impact factor: 5.191

4.  Synthesis of 3-O-demethylfortimicins.

Authors:  J R Martin; P Johnson; J Tadanier; A Goldstein
Journal:  Antimicrob Agents Chemother       Date:  1980-11       Impact factor: 5.191

5.  In vitro and in vivo antibacterial activity of KW1070, a new aminoglycoside antibiotic.

Authors:  Y Ohashi; H Kawabe; K Sato; N Nakamura; S Kurashige; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1980-02       Impact factor: 5.191

6.  Antibacterial activity of fortimicin A compared with those of five other aminoglycosides, and factors affecting susceptibility tests.

Authors:  C Thornsberry; A L Barry; R N Jones; C N Baker; R E Badal; R R Packer
Journal:  Antimicrob Agents Chemother       Date:  1981-01       Impact factor: 5.191

7.  Fortimicin A: collaborative in vitro susceptibility. Comparison with amikacin and gentamicin against 11,840 clinical bacterial isolates.

Authors:  R N Jones; A L Barry; P C Fuchs; T L Gavan; H M Sommers; E H Gerlach
Journal:  Antimicrob Agents Chemother       Date:  1979-12       Impact factor: 5.191

8.  Compound A49759, the 3-O-demethyl derivative of fortimicin A: in vitro comparison with six other aminoglycoside antibiotics.

Authors:  R N Jones; C Thornsberry; A L Barry; R R Packer; C N Baker; R E Badal
Journal:  Antimicrob Agents Chemother       Date:  1980-11       Impact factor: 5.191

9.  Proposed zone standards for interpretation of fortimicin A disk diffusion tests.

Authors:  A L Barry; C Thornsberry; R N Jones
Journal:  J Clin Microbiol       Date:  1983-08       Impact factor: 5.948

10.  A novel, highly efficient gene-cloning system for Micromonospora strains.

Authors:  M Hasegawa; T Dairi; T Ohta; E Hashimoto
Journal:  J Bacteriol       Date:  1991-11       Impact factor: 3.490
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