Cost-effective anesthesia: desflurane versus propofol in outpatient surgery.

This study compared the costs of desflurane and propofol as maintenance anesthetic agents in outpatient surgery. Recovery time and related drug expenses were included in the cost comparison. Fifty-three ASA physical status I and II patients were randomly assigned to receive a maintenance anesthetic of either desflurane with 50% nitrous oxide or propofol with 50% nitrous oxide. All patients received a propofol induction and were administered narcotics, sedatives, muscle relaxants, reversal agents, and antiemetics as determined necessary by the anesthesia provider. The mean propofol cost was $31.88 +/- 14.44, whereas, the mean desflurane cost was $12.99 +/- 7.61 (P < .05). The mean cost of all medications, anesthetics, and ancillary agents included was $57.97 +/- 20.22 for the propofol group and $34.86 +/- 14.13 for the desflurane group (P < .05). Of the desflurane patients, 41% experienced nausea compared to 12% of the propofol patients (P < .05). There was no significant difference between the recovery times of the two groups. Desflurane was more cost-effective than propofol. Although desflurane patients experienced more nausea, this did not affect their discharge time.

RCT Entities:   Population Interventions Outcomes