Literature DB >> 892610

Selective IgA deficiency and Crohn's disease: report of two cases.

H J Hodgson, D P Jewell.   

Abstract

Two patients are described with Crohn's disease and selective IgA deficiency. Serum IgA was undetectable in each case, and immunoperoxidase studies of the lamina propria showed a gross diminution of IgA-bearing plasma cells. Peripheral blood lymphocytes, however, showed normal numbers of IgA-bearing lymphocytes. The typical clinical course and histology in these two patients suggest that IgA-mediated responses in the mucosa are not involved in the pathogenesis of Crohn's disease.

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Year:  1977        PMID： 892610      PMCID： PMC1411720          DOI： 10.1136/gut.18.8.644

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  13 in total

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Authors:  A R Hayward; M F Greaves
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2.  Immune imbalance in dysgammaglobulinaemia type IV.

Authors:  J R Hobbs
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3.  An immunoperoxidase technique for the identification of gastrin-producing cells.

Authors:  J Piris; R Whitehead
Journal:  J Clin Pathol       Date:  1974-10       Impact factor: 3.411

4.  Agammaglobulinaemia with B lymphocytes. Specific defect of plasma-cell differentiation.

Authors:  M D Cooper; A R Lawton; D E Bockman
Journal:  Lancet       Date:  1971-10-09       Impact factor: 79.321

5.  Selective IgA deficiency: presentation of 30 cases and a review of the literature.

Authors:  A J Ammann; R Hong
Journal:  Medicine (Baltimore)       Date:  1971-05       Impact factor: 1.889

6.  Immunoglobulin deficiency and regional enteritis.

Authors:  J Söltoft; L Petersen; P Kruse
Journal:  Scand J Gastroenterol       Date:  1972       Impact factor: 2.423

7.  The liver in Crohn's disease.

Authors:  A D Perrett; G Higgins; H H Johnston; G R Massarella; S C Truelove; R Wrigth
Journal:  Q J Med       Date:  1971-04

8.  The level of antibodies to the proteins of cow's milk in the serum of normal human infants.

Authors:  M GUNTHER; R ASCHAFFENBURG; R H MATTHEWS; W E PARISH; R R COOMBS
Journal:  Immunology       Date:  1960-10       Impact factor: 7.397

9.  Serum concentration of 19 serum proteins in Crohn's disease and ulcerative colitis.

Authors:  B Weeke; S Jarnum
Journal:  Gut       Date:  1971-04       Impact factor: 23.059

10.  The plasma cells in inflammatory disease of the colon: a quantitative study.

Authors:  J M Skinner; R Whitehead
Journal:  J Clin Pathol       Date:  1974-08       Impact factor: 3.411
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  3 in total

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3.  An unusual inflammatory lesion of the jejunum in a patient with late onset immunoglobulin deficiency.

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