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Literature DB >> 8925129

Evaluation of the prognostic significance of nm23/NDP kinase and cathepsin D in anal carcinomas. An immunohistochemical study.

Abstract

Reduced expression of nm23/NDP kinase and increased expression of cathepsin D seem to be correlated with a high metastatic potential for a variety of malignancies. Nm23/NDP kinase and cathepsin D have been correlated with several clinical variables, including survival in 96 patients with squamous cell carcinoma of the anal canal. Immunohistochemical methods were used on paraffin-embedded biopsies. Seventy-six (79%) anal carcinomas were nm23/NDP kinase positive, whereas 35 (36%) and 28 (29%) of the cases were cathepsin D positive in tumor cells and stromal cells, respectively. We have found no indication that the extent of cathepsin D staining has any prognostic significance. The overall survival of patients with tumours positive for nm23/NDP kinase in the cytoplasm was significantly shorter than that of patients with anal carcinomas negative for nm23/NDP kinase.

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Year: 1996 PMID： 8925129 DOI： 10.1007/bf00193935

Source DB: PubMed Journal: Virchows Arch ISSN： 0945-6317 Impact factor: 4.064

38 in total

1. Immunohistochemical detection of nm23/NDP kinase and cathepsin D in medullary carcinomas of the thyroid gland.

Authors: R Holm; J Høie; O Kaalhus; J M Nesland
Journal: Virchows Arch Date: 1995 Impact factor: 4.064

2. Oestrogen receptor, progesterone receptor, pS2, ERD5, HSP27 and cathepsin D in invasive ductal breast carcinomas.

Authors: J Hurlimann; S Gebhard; F Gomez
Journal: Histopathology Date: 1993-09 Impact factor: 5.087

3. Alterations in growth properties of human papilloma virus type 16 immortalised human cervical keratinocyte cell line correlate with amplification and overexpression of c-myc oncogene.

Authors: T Crook; I Greenfield; J Howard; M Stanley
Journal: Oncogene Date: 1990-04 Impact factor: 9.867

4. Reduced expression of nm23-H1, but not of nm23-H2, is concordant with the frequency of lymph-node metastasis of human breast cancer.

Authors: Y Tokunaga; T Urano; K Furukawa; H Kondo; T Kanematsu; H Shiku
Journal: Int J Cancer Date: 1993-08-19 Impact factor: 7.396

5. A prospective study of the prognostic value of cathepsin D levels in breast cancer cytosol.

Authors: P Pujol; T Maudelonde; J P Daures; P Rouanet; J P Brouillet; H Pujol; H Rochefort
Journal: Cancer Date: 1993-03-15 Impact factor: 6.860

6. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections.

Authors: G Cattoretti; M H Becker; G Key; M Duchrow; C Schlüter; J Galle; J Gerdes
Journal: J Pathol Date: 1992-12 Impact factor: 7.996

7. High levels of nm23-H1 and nm23-H2 messenger RNA in human squamous-cell lung carcinoma are associated with poor differentiation and advanced tumor stages.

Authors: M Engel; B Theisinger; T Seib; G Seitz; H Huwer; K D Zang; C Welter; S Dooley
Journal: Int J Cancer Date: 1993-09-30 Impact factor: 7.396

Evaluation of the prognostic significance of nm23/NDP kinase and cathepsin D in anal carcinomas. An immunohistochemical study.

1. Immunohistochemical detection of nm23/NDP kinase and cathepsin D in medullary carcinomas of the thyroid gland.

2. Oestrogen receptor, progesterone receptor, pS2, ERD5, HSP27 and cathepsin D in invasive ductal breast carcinomas.

3. Alterations in growth properties of human papilloma virus type 16 immortalised human cervical keratinocyte cell line correlate with amplification and overexpression of c-myc oncogene.

4. Reduced expression of nm23-H1, but not of nm23-H2, is concordant with the frequency of lymph-node metastasis of human breast cancer.

5. A prospective study of the prognostic value of cathepsin D levels in breast cancer cytosol.

6. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections.

7. High levels of nm23-H1 and nm23-H2 messenger RNA in human squamous-cell lung carcinoma are associated with poor differentiation and advanced tumor stages.

8. High levels of Nm23 gene expression in advanced stage of thyroid carcinomas.

9. Inverse association of nm23-H1 expression by colorectal cancer with liver metastasis.

10. High level of Nm23-H1 gene expression is associated with local colorectal cancer progression not with metastases.

1. Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas.

Review 2. Prognostic biomarkers in squamous cell carcinoma of the anus: a systematic review.