Literature DB >> 8918193

Telomerase and cancer: revisiting the telomere hypothesis.

C Autexier1, C W Greider.   

Abstract

Telomerase is a ribonucleoprotein DNA polymerase that elongates telomeres in eukaryotes. The telomere hypothesis implicates short telomere length and telomerase activation as critical players in cellular immortalization and cancer. In this review, we refine the original telomere hypothesis to address the results of recent studies on telomerase and telomere length regulation.

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Year:  1996        PMID： 8918193

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  43 in total

1.  Expression of hTERT and hTR in cis reconstitutes and active human telomerase ribonucleoprotein.

Authors:  F Bachand; G Kukolj; C Autexier
Journal:  RNA       Date:  2000-05       Impact factor: 4.942

2.  RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase.

Authors:  S Le; J K Moore; J E Haber; C W Greider
Journal:  Genetics       Date:  1999-05       Impact factor: 4.562

3.  Impaired germinal center reaction in mice with short telomeres.

Authors:  E Herrera; C Martínez-A; M A Blasco
Journal:  EMBO J       Date:  2000-02-01       Impact factor: 11.598

Review 4.  The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance.

Authors:  Jonathan H Teichroeb; Joohwan Kim; Dean H Betts
Journal:  RNA Biol       Date:  2016-01-19       Impact factor: 4.652

5.  Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats.

Authors:  J M Zijlmans; U M Martens; S S Poon; A K Raap; H J Tanke; R K Ward; P M Lansdorp
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-08       Impact factor: 11.205

6.  Novel isolation and biochemical characterization of immortalized fibroblasts for tissue engineering vocal fold lamina propria.

Authors:  Xia Chen; Susan L Thibeault
Journal:  Tissue Eng Part C Methods       Date:  2009-06       Impact factor: 3.056

7.  Developmental control of telomere lengths and telomerase activity in plants.

Authors:  K Riha; J Fajkus; J Siroky; B Vyskot
Journal:  Plant Cell       Date:  1998-10       Impact factor: 11.277

8.  Telomerase catalysis: a phylogenetically conserved reverse transcriptase.

Authors:  V Lundblad
Journal:  Proc Natl Acad Sci U S A       Date:  1998-07-21       Impact factor: 11.205

9.  Expression of mouse telomerase catalytic subunit in embryos and adult tissues.

Authors:  L Martín-Rivera; E Herrera; J P Albar; M A Blasco
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

10.  Gene expression levels of human shelterin complex and shelterin-associated factors regulated by the topoisomerase II inhibitors doxorubicin and etoposide in human cultured cells.

Authors:  Masahiro Kato; Masahiro Nakayama; Minako Agata; Kenichi Yoshida
Journal:  Tumour Biol       Date:  2012-12-18
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