Literature DB >> 9207107

Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats.

J M Zijlmans1, U M Martens, S S Poon, A K Raap, H J Tanke, R K Ward, P M Lansdorp.   

Abstract

The ultra-long telomeres that have been observed in mice are not in accordance with the concept that critical telomere shortening is related to aging and immortalization. Here, we have used quantitative fluorescence in situ hybridization to estimate (T2AG3)n lengths of individual telomeres in various mouse strains. Telomere lengths were very heterogeneous, but specific chromosomes of bone marrow cells and skin fibroblasts from individual mice had similar telomere lengths. We estimate that the shortest telomeres are around 10 kb in length, indicating that each mouse cell has a few telomeres with (T2AG3)n lengths within the range of human telomeres. These short telomeres may be critical in limiting the replicative potential of murine cells.

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Mesh：

Year:  1997        PMID： 9207107      PMCID： PMC23837          DOI： 10.1073/pnas.94.14.7423

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

Review 1.  Genetics and molecular biology of telomeres.

Authors:  H Biessmann; J M Mason
Journal:  Adv Genet       Date:  1992       Impact factor: 1.944

2.  Structure and polymorphism of human telomere-associated DNA.

Authors:  W R Brown; P J MacKinnon; A Villasanté; N Spurr; V J Buckle; M J Dobson
Journal:  Cell       Date:  1990-10-05       Impact factor: 41.582

3.  Telomere-telomere recombination provides an express pathway for telomere acquisition.

Authors:  S S Wang; V A Zakian
Journal:  Nature       Date:  1990-05-31       Impact factor: 49.962

4.  Mouse minor satellite DNA genetically maps to the centromere and is physically linked to the proximal telomere.

Authors:  D Kipling; H E Ackford; B A Taylor; H J Cooke
Journal:  Genomics       Date:  1991-10       Impact factor: 5.736

5.  Hypervariable ultra-long telomeres in mice.

Authors:  D Kipling; H J Cooke
Journal:  Nature       Date:  1990-09-27       Impact factor: 49.962

6.  Extensive telomere repeat arrays in mouse are hypervariable.

Authors:  J A Starling; J Maule; N D Hastie; R C Allshire
Journal:  Nucleic Acids Res       Date:  1990-12-11       Impact factor: 16.971

Review 7.  Cytogenetic methods for the mouse: preparation of chromosomes, karyotyping, and in situ hybridization.

Authors:  J J Lee; D Warburton; E J Robertson
Journal:  Anal Biochem       Date:  1990-08-15       Impact factor: 3.365

8.  Telomeres shorten during ageing of human fibroblasts.

Authors:  C B Harley; A B Futcher; C W Greider
Journal:  Nature       Date:  1990-05-31       Impact factor: 49.962

9.  Telomere length predicts replicative capacity of human fibroblasts.

Authors:  R C Allsopp; H Vaziri; C Patterson; S Goldstein; E V Younglai; A B Futcher; C W Greider; C B Harley
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

10.  Long-term erythropoiesis from constant numbers of CD34+ cells in serum-free cultures initiated with highly purified progenitor cells from human bone marrow.

Authors:  P M Lansdorp; W Dragowska
Journal:  J Exp Med       Date:  1992-06-01       Impact factor: 14.307
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  170 in total

1.  Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops.

Authors:  K G Murti; D M Prescott
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

2.  Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA.

Authors:  H Niida; Y Shinkai; M P Hande; T Matsumoto; S Takehara; M Tachibana; M Oshimura; P M Lansdorp; Y Furuichi
Journal:  Mol Cell Biol       Date:  2000-06       Impact factor: 4.272

3.  An anchorage nuclear structure for telomeric DNA repeats in HeLa cells.

Authors:  G Pierron; F Puvion-Dutilleul
Journal:  Chromosome Res       Date:  1999       Impact factor: 5.239

4.  Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.

Authors:  E Samper; J M Flores; M A Blasco
Journal:  EMBO Rep       Date:  2001-08-23       Impact factor: 8.807

5.  A central role for Plasmodium falciparum subtelomeric regions in spatial positioning and telomere length regulation.

Authors:  Luisa M Figueiredo; Lúcio H Freitas-Junior; Emmanuel Bottius; Jean-Christophe Olivo-Marin; Artur Scherf
Journal:  EMBO J       Date:  2002-02-15       Impact factor: 11.598

6.  Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert.

Authors:  Yie Liu; Hue Kha; Mark Ungrin; Murray O Robinson; Lea Harrington
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-19       Impact factor: 11.205

7.  Telomere length assessment in human archival tissues: combined telomere fluorescence in situ hybridization and immunostaining.

Authors:  Alan K Meeker; Wesley R Gage; Jessica L Hicks; Inpakala Simon; Jonathan R Coffman; Elizabeth A Platz; Gerrun E March; Angelo M De Marzo
Journal:  Am J Pathol       Date:  2002-04       Impact factor: 4.307

8.  Chromosome healing in mouse embryonic stem cells.

Authors:  C N Sprung; G E Reynolds; M Jasin; J P Murnane
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-08       Impact factor: 11.205

9.  DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.

Authors:  W M Tong; M P Hande; P M Lansdorp; Z Q Wang
Journal:  Mol Cell Biol       Date:  2001-06       Impact factor: 4.272

10.  No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells.

Authors:  Natalie Erdmann; Lea A Harrington
Journal:  DNA Repair (Amst)       Date:  2008-12-25
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