Literature DB >> 891804

Synthesis and properties of Praziquantel, a novel broad spectrum anthelmintic with excellent activity against Schistosomes and Cestodes.

J Seubert, R Pohlke, F Loebich.   

Abstract

Synthesis and properties of 2-cyclohexylcarbonyl-1,3,4,6,7,11b-hexahydro-2H-pyrazino [2,1-a] isoquinolin-4-one, a novel anthelmintic with excellent activity against all species of Schistosomes pathogenic to man and a wide range of cestodes, will be reported.

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Year:  1977        PMID： 891804     DOI： 10.1007/bf01945954

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  3 in total

1.  [The efficacy of praziquantel against tapeworms in experimentally infected dogs and cats].

Authors:  M Rommel; H Grelck; F Hörchner
Journal:  Berl Munch Tierarztl Wochenschr       Date:  1976-07-01       Impact factor: 0.328

Review 2.  Anthelmintics, new and old.

Authors:  H W Brown
Journal:  Clin Pharmacol Ther       Date:  1969 Jan-Feb       Impact factor: 6.875

3.  The schistosomiasis problem.

Authors:  T P Pesigan
Journal:  World Med J       Date:  1967 Jan-Feb
  3 in total
  21 in total

Review 1.  Combination chemotherapy of schistosomiasis in laboratory studies and clinical trials.

Authors:  Jürg Utzinger; Jennifer Keiser; Xiao Shuhua; Marcel Tanner; Burton H Singer
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

2.  Effect of the in vivo activity of dihydroartemisinin against Schistosoma mansoni infection in mice.

Authors:  Hong-jun Li; Wei Wang; Guo-li Qu; You-zi Li; Yong-hui Tao; Yun-tian Xing; Xiao-ting Wang; Yang Dai; Jian-ying Wei; Jian-rong Dai; Gerald C Coles; You-sheng Liang
Journal:  Parasitol Res       Date:  2011-10-18       Impact factor: 2.289

Review 3.  New insight into praziquantel against various developmental stages of schistosomes.

Authors:  Wei Wu; Wei Wang; Yi-Xin Huang
Journal:  Parasitol Res       Date:  2011-10-08       Impact factor: 2.289

Review 4.  Susceptibility or resistance of praziquantel in human schistosomiasis: a review.

Authors:  Wei Wang; Li Wang; You-Sheng Liang
Journal:  Parasitol Res       Date:  2012-10-07       Impact factor: 2.289

5.  MCR synthesis of praziquantel derivatives.

Authors:  Haixia Liu; Samia William; Eberhardt Herdtweck; Sanaa Botros; Alexander Dömling
Journal:  Chem Biol Drug Des       Date:  2012-01-30       Impact factor: 2.817

6.  Clinical pharmacology in normal volunteers of praziquantel, a new drug against schistosomes and cestodes. An example of a complex study covering both tolerance and pharmacokinetics.

Authors:  G Leopold; W Ungethüm; E Groll; H W Diekmann; H Nowak; D H Wegner
Journal:  Eur J Clin Pharmacol       Date:  1978-12-01       Impact factor: 2.953

Review 7.  Application of praziquantel in schistosomiasis japonica control strategies in China.

Authors:  Wei Wu; Yixin Huang
Journal:  Parasitol Res       Date:  2013-01-29       Impact factor: 2.289

8.  [The efficacy of praziquantel against experimental cysticercosis and hydatidosis (author's transl)].

Authors:  H Thomas; R Gönnert
Journal:  Z Parasitenkd       Date:  1978-04-20

9.  Combination chemotherapy against Clonorchis sinensis: experiments with artemether, artesunate, OZ78, praziquantel, and tribendimidine in a rat model.

Authors:  Jennifer Keiser; Shu-Hua Xiao; Thomas A Smith; Jürg Utzinger
Journal:  Antimicrob Agents Chemother       Date:  2009-07-06       Impact factor: 5.191

10.  Is there a reduced sensitivity of dihydroartemisinin against praziquantel-resistant Schistosoma japonicum?

Authors:  Wei Wang; Hong-Jun Li; Guo-Li Qu; Yun-Tian Xing; Zhen-Kun Yang; Jian-Rong Dai; You-Sheng Liang
Journal:  Parasitol Res       Date:  2013-10-22       Impact factor: 2.289
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