Literature DB >> 8917523

Chiral molecular self-assembly of phospholipid tubules: a circular dichroism study.

M S Spector1, K R Easwaran, G Jyothi, J V Selinger, A Singh, J M Schnur.   

Abstract

We report on spectroscopic studies of the chiral structure in phospholipid tubules formed in mixtures of alcohol and water. Synthetic phospholipids containing diacetylenic moieties in the acyl chains self-assemble into hollow, cylindrical tubules in appropriate conditions. Circular dichroism provides a direct measure of chirality of the molecular structure. We find that the CD spectra of tubules formed in mixtures of alcohol and water depends strongly on the alcohol used and the lipid concentration. The relative spectral intensity of different circular dichroism bands correlates with the number of bilayers observed using microscopy. The results provide experimental evidence that tubule formation is based on chiral packing of the lipid molecules and that interbilayer interactions are important to the tubule structure.

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Year:  1996        PMID： 8917523      PMCID： PMC24025          DOI： 10.1073/pnas.93.23.12943

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  12 in total

1.  Melting of phospholipid tubules.

Authors: 
Journal:  Phys Rev Lett       Date:  1996-05-06       Impact factor: 9.161

2.  Effect of alcohol chain length on tubule formation in 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine.

Authors:  B R Ratna; S Baral-Tosh; B Kahn; J M Schnur; A S Rudolph
Journal:  Chem Phys Lipids       Date:  1992-11       Impact factor: 3.329

3.  Theory of chiral lipid tubules.

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Journal:  Phys Rev Lett       Date:  1993-12-13       Impact factor: 9.161

4.  Theory of cylindrical tubules and helical ribbons of chiral lipid membranes.

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Journal:  Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics       Date:  1996-04

5.  Theory of helical structures of tilted chiral lipid bilayers.

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Journal:  Phys Rev A       Date:  1991-06-15       Impact factor: 3.140

6.  Elastic free energy of anisotropic helical ribbons as metastable intermediates in the crystallization of cholesterol.

Authors:  D S Chung; G B Benedek; F M Konikoff; J M Donovan
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-01       Impact factor: 11.205

7.  Polymerizable phospholipid analogues--new stable biomembrane and cell models.

Authors:  H H Hub; B Hupfer; H Koch; H Ringsdorf
Journal:  Angew Chem Int Ed Engl       Date:  1980       Impact factor: 15.336

8.  Diacetylenic lipid tubules: experimental evidence for a chiral molecular architecture.

Authors:  J M Schnur; B R Ratna; J V Selinger; A Singh; G Jyothi; K R Easwaran
Journal:  Science       Date:  1994-05-13       Impact factor: 47.728

9.  Diacetylenic lipid microstructures: structural characterization by X-ray diffraction and comparison with the saturated phosphatidylcholine analogue.

Authors:  M Caffrey; J Hogan; A S Rudolph
Journal:  Biochemistry       Date:  1991-02-26       Impact factor: 3.162

10.  Phospholipid polymers--synthesis and spectral characteristics.

Authors:  D S Johnston; S Sanghera; M Pons; D Chapman
Journal:  Biochim Biophys Acta       Date:  1980-10-16
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5.  Modulation of nanotube formation by structural modifications of sphingolipids.

Authors:  V S Kulkarni; J M Boggs; R E Brown
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Journal:  J Phys Chem B       Date:  2008-09-25       Impact factor: 2.991

7.  Application of a Krypton-Chlorine Excilamp To Control Alicyclobacillus acidoterrestris Spores in Apple Juice and Identification of Its Sporicidal Mechanism.

Authors:  Jun-Won Kang; Hak-Nyeong Hong; Dong-Hyun Kang
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8.  Reconstruction of Average Subtracted Tubular Regions (RASTR) enables structure determination of tubular filaments by cryo-EM.

Authors:  Peter S Randolph; Scott M Stagg
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  8 in total

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