Literature DB >> 8915588

Changes in hippocampal gene expression associated with the induction of long-term potentiation.

L A Roberts1, M J Higgins, C T O'Shaughnessy, T W Stone, B J Morris.   

Abstract

The expression of four genes: zif/268, c-fos, tubulin and alpha Ca2+/calmodulin-dependent protein kinase II (alpha CAMKII) was studied following the induction of LTP in Schaffer collateral CA1 neurone synapses in rat hippocampal slices maintained in vitro. Levels of c-fos mRNA and tubulin (T26) mRNA in area CA1 were unchanged after induction of LTP, however, zif/268 and alpha CAMKII mRNA levels showed a significant increase compared to non-potentiated controls. It is possible, therefore, to measure changes in gene expression using in situ hybridisation following induction of LTP in vitro and these results strengthen the theory that zif/268 and alpha CAMKII are involved in some aspect of the induction or maintenance of hippocampal LTP.

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Year:  1996        PMID： 8915588     DOI： 10.1016/s0169-328x(96)00148-9

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  8 in total

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  8 in total

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